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Samuel Paul Gubbels

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-OTO General Operations

    Collapse Research 
    Collapse research activities and funding
    R03DC012432     (GUBBELS, SAMUEL PAUL)Feb 15, 2012 - Jan 31, 2015
    NIH/NIDCD
    Pluripotent Stem Cell Technology for the Study and treatment of Human hearing los
    Role: Principal Investigator
    R01DC013912     (GUBBELS, SAMUEL PAUL)Jun 1, 2014 - May 31, 2019
    NIH/NIDCD
    Inner Ear Progenitor and Hair Cell-like Cells From Human Pluripotent Stem Cells
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Lundberg EMH, Strong D, Anderson M, Kaizer AM, Gubbels S. Do Patients Benefit From a Cochlear Implant When They Qualify Only in the Presence of Background Noise? Otol Neurotol. 2021 Feb 01; 42(2):251-259. PMID: 33229878.
      View in: PubMed
    2. Youssef AS, Arnone GD, Farell NF, Thompson JA, Ramakrishnan VR, Gubbels S, Cohen-Gadol AA, Cass S, Labib MA. The Combined Endoscopic Endonasal Far Medial and Open Postauricular Transtemporal Approaches As a Lesser Invasive Approach to the Jugular Foramen: Anatomic Morphometric Study With Case Illustration. Oper Neurosurg (Hagerstown). 2020 09 15; 19(4):471-479. PMID: 32510567.
      View in: PubMed
    3. Bootpetch TC, Hafrén L, Elling CL, Baschal EE, Manichaikul AW, Pine HS, Szeremeta W, Scholes MA, Cass SP, Larson ED, Chan KH, Ishaq R, Prager JD, Shaikh RS, Gubbels SP, Yousaf A, Wine TM, Bamshad MJ, Yoon PJ, Jenkins HA, Nickerson DA, Streubel SO, Friedman NR, Frank DN, Einarsdottir E, Kere J, Riazuddin S, Daly KA, Leal SM, Ryan AF, Mattila PS, Ahmed ZM, Sale MM, Chonmaitree T, Santos-Cortez RLP. Multi-omic studies on missense PLG variants in families with otitis media. Sci Rep. 2020 09 14; 10(1):15035. PMID: 32929111.
      View in: PubMed
    4. Cass ND, Schopper MA, Lubin JA, Fishbein L, Gubbels SP. The Changing Paradigm of Head and Neck Paragangliomas: What Every Otolaryngologist Needs to Know. Ann Otol Rhinol Laryngol. 2020 Nov; 129(11):1135-1143. PMID: 32486832.
      View in: PubMed
    5. Hunt AA, Cass ND, Coughlin A, Gubbels SP. Time-based Assessment of Hearing Preservation Rates After Microsurgical Resection of Vestibular Schwannomas: A Systematic Review. Otol Neurotol. 2020 Jun; 41(5):679-685. PMID: 32150025.
      View in: PubMed
    6. Lee S, Dondzillo A, Gubbels SP, Raphael Y. Practical aspects of inner ear gene delivery for research and clinical applications. Hear Res. 2020 Sep 01; 394:107934. PMID: 32204962.
      View in: PubMed
    7. Misch ES, Banakis Hartl RM, Gubbels SP, Greene NT. Risks of Intracochlear Pressures From Laser Stapedotomy. Otol Neurotol. 2020 Mar; 41(3):308-317. PMID: 31746814.
      View in: PubMed
    8. Baschal EE, Larson ED, Bootpetch Roberts TC, Pathak S, Frank G, Handley E, Dinwiddie J, Moloney M, Yoon PJ, Gubbels SP, Scholes MA, Cass SP, Jenkins HA, Frank DN, Yang IV, Schwartz DA, Ramakrishnan VR, Santos-Cortez RLP. Identification of Novel Genes and Biological Pathways That Overlap in Infectious and Nonallergic Diseases of the Upper and Lower Airways Using Network Analyses. Front Genet. 2019; 10:1352. PMID: 32010199.
      View in: PubMed
    9. Cass ND, Honce JM, O'Dell AL, Gubbels SP. First MRI With New Cochlear Implant With Rotatable Internal Magnet System and Proposal for Standardization of Reporting Magnet-Related Artifact Size. Otol Neurotol. 2019 08; 40(7):883-891. PMID: 31219967.
      View in: PubMed
    10. Larson ED, Magno JPM, Steritz MJ, Llanes EGDV, Cardwell J, Pedro M, Roberts TB, Einarsdottir E, Rosanes RAQ, Greenlee C, Santos RAP, Yousaf A, Streubel SO, Santos ATR, Ruiz AG, Lagrana-Villagracia SM, Ray D, Yarza TKL, Scholes MA, Anderson CB, Acharya A, Gubbels SP, Bamshad MJ, Cass SP, Lee NR, Shaikh RS, Nickerson DA, Mohlke KL, Prager JD, Cruz TLG, Yoon PJ, Abes GT, Schwartz DA, Chan AL, Wine TM, Cutiongco-de la Paz EM, Friedman N, Kechris K, Kere J, Leal SM, Yang IV, Patel JA, Tantoco MLC, Riazuddin S, Chan KH, Mattila PS, Reyes-Quintos MRT, Ahmed ZM, Jenkins HA, Chonmaitree T, Hafrén L, Chiong CM, Santos-Cortez RLP. A2ML1 and otitis media: novel variants, differential expression, and relevant pathways. Hum Mutat. 2019 08; 40(8):1156-1171. PMID: 31009165.
      View in: PubMed
    11. Santos-Cortez RLP, Chiong CM, Frank DN, Ryan AF, Giese APJ, Bootpetch Roberts T, Daly KA, Steritz MJ, Szeremeta W, Pedro M, Pine H, Yarza TKL, Scholes MA, Llanes EGDV, Yousaf S, Friedman N, Tantoco MLC, Wine TM, Labra PJ, Benoit J, Ruiz AG, de la Cruz RAR, Greenlee C, Yousaf A, Cardwell J, Nonato RMA, Ray D, Ong KMC, So E, Robertson CE, Dinwiddie J, Lagrana-Villagracia SM, Gubbels SP, Shaikh RS, Cass SP, Einarsdottir E, Lee NR, Schwartz DA, Gloria-Cruz TLI, Bamshad MJ, Yang IV, Kere J, Abes GT, Prager JD, Riazuddin S, Chan AL, Yoon PJ, Nickerson DA, Cutiongco-de la Paz EM, Streubel SO, Reyes-Quintos MRT, Jenkins HA, Mattila P, Chan KH, Mohlke KL, Leal SM, Hafrén L, Chonmaitree T, Sale MM, Ahmed ZM. FUT2 Variants Confer Susceptibility to Familial Otitis Media. Am J Hum Genet. 2018 11 01; 103(5):679-690. PMID: 30401457.
      View in: PubMed
    12. Coughlin AR, Hunt AA, Gubbels SP. Is hearing preserved following radiotherapy for vestibular schwannoma? Laryngoscope. 2019 04; 129(4):775-776. PMID: 30284268.
      View in: PubMed
    13. Kunigelis KE, Craig D, Yang A, Gubbels S, Youssef AS. Presigmoid Approach to Dumbbell Trigeminal Schwannoma. J Neurol Surg B Skull Base. 2018 Dec; 79(Suppl 5):S391-S392. PMID: 30456036.
      View in: PubMed
    14. Maxwell AK, Takeda H, Gubbels SP. Primary Middle Ear Mucosal Melanoma: Case Report and Comprehensive Literature Review of 21 Cases of Primary Middle Ear and Eustachian Tube Melanoma. Ann Otol Rhinol Laryngol. 2018 Nov; 127(11):856-863. PMID: 30103615.
      View in: PubMed
    15. Cass ND, Gubbels SP, Portnuff CDF. Sudden Bilateral Hearing Loss, Tinnitus, and Vertigo as Presenting Symptoms of Chronic Myeloid Leukemia. Ann Otol Rhinol Laryngol. 2018 Oct; 127(10):731-734. PMID: 30032641.
      View in: PubMed
    16. Takeda H, Dondzillo A, Randall JA, Gubbels SP. Challenges in Cell-Based Therapies for the Treatment of Hearing Loss. Trends Neurosci. 2018 11; 41(11):823-837. PMID: 30033182.
      View in: PubMed
    17. Devare J, Gubbels S, Raphael Y. Outlook and future of inner ear therapy. Hear Res. 2018 10; 368:127-135. PMID: 29804723.
      View in: PubMed
    18. Coughlin AR, Willman TJ, Gubbels SP. Systematic Review of Hearing Preservation After Radiotherapy for Vestibular Schwannoma. Otol Neurotol. 2018 03; 39(3):273-283. PMID: 29342035.
      View in: PubMed
    19. Banakis Hartl RM, Mattingly JK, Greene NT, Farrell NF, Gubbels SP, Tollin DJ. Drill-induced Cochlear Injury During Otologic Surgery: Intracochlear Pressure Evidence of Acoustic Trauma. Otol Neurotol. 2017 08; 38(7):938-947. PMID: 28598950.
      View in: PubMed
    20. Mowry SE, Woodson E, Gubbels S, Carfrae M, Hansen MR. A simple assessment tool for evaluation of cadaveric temporal bone dissection. Laryngoscope. 2018 02; 128(2):451-455. PMID: 28425611.
      View in: PubMed
    21. Bhattacharyya N, Gubbels SP, Schwartz SR, Edlow JA, El-Kashlan H, Fife T, Holmberg JM, Mahoney K, Hollingsworth DB, Roberts R, Seidman MD, Steiner RW, Do BT, Voelker CC, Waguespack RW, Corrigan MD. Clinical Practice Guideline: Benign Paroxysmal Positional Vertigo (Update). Otolaryngol Head Neck Surg. 2017 03; 156(3_suppl):S1-S47. PMID: 28248609.
      View in: PubMed
    22. Bhattacharyya N, Gubbels SP, Schwartz SR, Edlow JA, El-Kashlan H, Fife T, Holmberg JM, Mahoney K, Hollingsworth DB, Roberts R, Seidman MD, Prasaad Steiner RW, Tsai Do B, Voelker CC, Waguespack RW, Corrigan MD. Clinical Practice Guideline: Benign Paroxysmal Positional Vertigo (Update) Executive Summary. Otolaryngol Head Neck Surg. 2017 03; 156(3):403-416. PMID: 28248602.
      View in: PubMed
    23. Hildebrand MS, Newton SS, Gubbels SP, Sheffield AM, Kochhar A, de Silva MG, Dahl HM, Rose SD, Behlke MA, Smith RJ. Advances in Molecular and Cellular Therapies for Hearing Loss. Mol Ther. 2008 Feb; 16(2):224-236. PMID: 28178538.
      View in: PubMed
    24. Kennedy TA, Connell N, Szczykutowicz T, Schafer S, Royalty K, Nace S, Gartrell B, Gubbels S. Flat-Panel CT for Cochlear Implant Electrode Imaging: Comparison to Multi-Detector CT. Otol Neurotol. 2016 12; 37(10):1646-1653. PMID: 27668790.
      View in: PubMed
    25. Gubbels SP, Gartrell BC, Ploch JL, Hanson KD. Can routine office-based audiometry predict cochlear implant evaluation results? Laryngoscope. 2017 01; 127(1):216-222. PMID: 27797418.
      View in: PubMed
    26. Chow CL, Trivedi P, Pyle MP, Matulle JT, Fettiplace R, Gubbels SP. Evaluation of Nestin Expression in the Developing and Adult Mouse Inner Ear. Stem Cells Dev. 2016 10 01; 25(19):1419-32. PMID: 27474107.
      View in: PubMed
    27. Condell O, Gubbels S, Nielsen J, Espenhain L, Frimodt-Møller N, Engberg J, Møller JK, Ellermann-Eriksen S, Schønheyder HC, Voldstedlund M, Mølbak K, Kristensen B. Automated surveillance system for hospital-acquired urinary tract infections in Denmark. J Hosp Infect. 2016 Jul; 93(3):290-6. PMID: 27157847.
      View in: PubMed
    28. Britt CJ, Coughlin AR, Gubbels SP. Bone-anchored hearing aid and skin graft removal with subsequent cochlear implantation. Laryngoscope. 2016 11; 126(11):2601-2604. PMID: 26864146.
      View in: PubMed
    29. Chow CL, Guo W, Trivedi P, Zhao X, Gubbels SP. Characterization of a unique cell population marked by transgene expression in the adult cochlea of nestin-CreER(T2)/tdTomato-reporter mice. J Comp Neurol. 2015 Jul 01; 523(10):1474-87. PMID: 25611038.
      View in: PubMed
    30. Gubbels S, Nielsen J, Voldstedlund M, Kristensen B, Schønheyder HC, Vandenbroucke-Grauls CM, Arpi M, Björnsdóttir MK, Knudsen JD, Dessau RB, Jensen TG, Kjældgaard P, Lemming L, Møller JK, Hansen DS, Mølbak K. Utilization of blood cultures in Danish hospitals: a population-based descriptive analysis. Clin Microbiol Infect. 2015 Apr; 21(4):344.e13-21. PMID: 25658520.
      View in: PubMed
    31. Gartrell BC, Jones HG, Kan A, Buhr-Lawler M, Gubbels SP, Litovsky RY. Investigating long-term effects of cochlear implantation in single-sided deafness: a best practice model for longitudinal assessment of spatial hearing abilities and tinnitus handicap. Otol Neurotol. 2014 Oct; 35(9):1525-32. PMID: 25158615.
      View in: PubMed
    32. Dang PT, Kennedy TA, Gubbels SP. Simultaneous, unilateral plugging of superior and posterior semicircular canal dehiscences to treat debilitating hyperacusis. J Laryngol Otol. 2014 Feb; 128(2):174-8. PMID: 24480590.
      View in: PubMed
    33. Gubbels SP, Dang PT. In response to "is nasopharyngoscopy necessary in adult-onset otitis media with effusion?". Laryngoscope. 2014 Nov; 124(11):E446. PMID: 24482112.
      View in: PubMed
    34. Gartrell BC, Gentry LR, Kennedy TA, Gubbels SP. Radiographic features of superior semicircular canal dehiscence in the setting of chronic ear disease. Otol Neurotol. 2014 Jan; 35(1):91-6. PMID: 24136312.
      View in: PubMed
    35. Gubbels SP, Zhang Q, Lenkowski PW, Hansen MR. Repair of posterior semicircular canal dehiscence from a high jugular bulb. Ann Otol Rhinol Laryngol. 2013 Apr; 122(4):269-72. PMID: 23697325.
      View in: PubMed
    36. Dang PT, Gubbels SP. Is nasopharyngoscopy necessary in adult-onset otitis media with effusion? Laryngoscope. 2013 Sep; 123(9):2081-2. PMID: 23404463.
      View in: PubMed
    37. Gartrell BC, Hansen MR, Gantz BJ, Gluth MB, Mowry SE, Aagaard-Kienitz BL, Baskaya MK, Gubbels SP. Facial and lower cranial neuropathies after preoperative embolization of jugular foramen lesions with ethylene vinyl alcohol. Otol Neurotol. 2012 Sep; 33(7):1270-5. PMID: 22801041.
      View in: PubMed
    38. Nickele CM, Akture E, Gubbels SP, Baskaya MK. A stepwise illustration of the translabyrinthine approach to a large cystic vestibular schwannoma. Neurosurg Focus. 2012 Sep; 33(3):E11. PMID: 22937845.
      View in: PubMed
    39. Gartrell BC, Kennedy TA, Gubbels SP. Bilateral duplicated internal carotid arteries presenting as middle ear masses: a case report and review of the literature. Ann Otol Rhinol Laryngol. 2012 Aug; 121(8):521-4. PMID: 22953658.
      View in: PubMed
    40. Gubbels S, Krause TG, Bragstad K, Perner A, Mølbak K, Glismann S. Burden and characteristics of influenza A and B in Danish intensive care units during the 2009/10 and 2010/11 influenza seasons. Epidemiol Infect. 2013 Apr; 141(4):767-75. PMID: 22793496.
      View in: PubMed
    41. Kuhn KG, Sørensen G, Torpdahl M, Kjeldsen MK, Jensen T, Gubbels S, Bjerager GO, Wingstrand A, Porsbo LJ, Ethelberg S. A long-lasting outbreak of Salmonella Typhimurium U323 associated with several pork products, Denmark, 2010. Epidemiol Infect. 2013 Feb; 141(2):260-8. PMID: 22717213.
      View in: PubMed
    42. Gubbels S, Bacci S, Laursen H, Hogenhaven H, Cowan S, Molbak K, Christiansen M. Description and analysis of 12 years of surveillance for Creutzfeldt-Jakob disease in Denmark, 1997 to 2008. Euro Surveill. 2012 Apr 12; 17(15). PMID: 22516048.
      View in: PubMed
    43. Sheffield AM, Gubbels SP, Hildebrand MS, Newton SS, Chiorini JA, Di Pasquale G, Smith RJ. Viral vector tropism for supporting cells in the developing murine cochlea. Hear Res. 2011 Jul; 277(1-2):28-36. PMID: 21530627.
      View in: PubMed
    44. Khachi S, Gubbels SP, Robinson RA, Hansen MR. Ganglion cyst presenting as an external auditory canal mass. Otolaryngol Head Neck Surg. 2011 Jan; 144(1):131-2. PMID: 21493405.
      View in: PubMed
    45. Woodson EA, Dempewolf RD, Gubbels SP, Porter AT, Oleson JJ, Hansen MR, Gantz BJ. Long-term hearing preservation after microsurgical excision of vestibular schwannoma. Otol Neurotol. 2010 Sep; 31(7):1144-52. PMID: 20679955.
      View in: PubMed
    46. Gurgel RK, Woodson EA, Lenkowski PW, Gubbels SP, Hansen MR. Zygomatic root abscess: a rare complication of otitis media. Otol Neurotol. 2010 Jul; 31(5):856-7. PMID: 19415039.
      View in: PubMed
    47. Dempewolf R, Gubbels S, Hansen MR. Acute radiographic workup of blunt temporal bone trauma: maxillofacial versus temporal bone CT. Laryngoscope. 2009 Mar; 119(3):442-8. PMID: 19235746.
      View in: PubMed
    48. Brigande JV, Gubbels SP, Woessner DW, Jungwirth JJ, Bresee CS. Electroporation-mediated gene transfer to the developing mouse inner ear. Methods Mol Biol. 2009; 493:125-39. PMID: 18839345.
      View in: PubMed
    49. Smith LK, Gubbels SP, MacArthur CJ, Milczuk HA. The effect of the palatoplasty method on the frequency of ear tube placement. Arch Otolaryngol Head Neck Surg. 2008 Oct; 134(10):1085-9. PMID: 18936356.
      View in: PubMed
    50. Gubbels SP, Woessner DW, Mitchell JC, Ricci AJ, Brigande JV. Functional auditory hair cells produced in the mammalian cochlea by in utero gene transfer. Nature. 2008 Sep 25; 455(7212):537-41. PMID: 18754012.
      View in: PubMed
    51. Gubbels SP, Selden NR, Delashaw JB, McMenomey SO. Spontaneous middle fossa encephalocele and cerebrospinal fluid leakage: diagnosis and management. Otol Neurotol. 2007 Dec; 28(8):1131-9. PMID: 17921911.
      View in: PubMed
    52. Hildebrand MS, Newton SS, Gubbels SP, Sheffield AM, Kochhar A, de Silva MG, Dahl HH, Rose SD, Behlke MA, Smith RJ. Advances in molecular and cellular therapies for hearing loss. Mol Ther. 2008 Feb; 16(2):224-36. PMID: 18223547.
      View in: PubMed
    53. Gubbels SP, Richardson M, Trune D, Bascom DA, Wax MK. Tracheal reconstruction with porcine small intestine submucosa in a rabbit model. Otolaryngol Head Neck Surg. 2006 Jun; 134(6):1028-35. PMID: 16730551.
      View in: PubMed
    54. Gubbels SP, McMenomey SO. Safety study of the Cochlear Nucleus 24 device with internal magnet in the 1.5 Tesla magnetic resonance imaging scanner. Laryngoscope. 2006 Jun; 116(6):865-71. PMID: 16735911.
      View in: PubMed
    55. Canning CA, Gubbels S, Chinn C, Wax M, Holland JM. Positron emission tomography scan to determine the need for neck dissection after chemoradiation for head and neck cancer: timing is everything. Laryngoscope. 2005 Dec; 115(12):2206-8. PMID: 16369167.
      View in: PubMed
    56. Gubbels SP, Barkhuizen A, Hwang PH. Head and neck manifestations of Wegener's granulomatosis. Otolaryngol Clin North Am. 2003 Aug; 36(4):685-705. PMID: 14567060.
      View in: PubMed
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