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Uma Maheshwari Muthurajan

TitleSr Research Associate
InstitutionUniversity of Colorado Boulder

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. McCauley MJ, Huo R, Becker N, Holte MN, Muthurajan UM, Rouzina I, Luger K, Maher LJ, Israeloff NE, Williams MC. Single and double box HMGB proteins differentially destabilize nucleosomes. Nucleic Acids Res. 2019 Jan 25; 47(2):666-678. PMID: 30445475.
      View in: PubMed
    2. Chassé MH, Muthurajan UM, Clark NJ, Kramer MA, Chakravarthy S, Irving T, Luger K. Biochemical and Biophysical Methods for Analysis of Poly(ADP-Ribose) Polymerase 1 and Its Interactions with Chromatin. Methods Mol Biol. 2017; 1608:231-253. PMID: 28695514.
      View in: PubMed
    3. Klein BJ, Muthurajan UM, Lalonde ME, Gibson MD, Andrews FH, Hepler M, Machida S, Yan K, Kurumizaka H, Poirier MG, Côté J, Luger K, Kutateladze TG. Bivalent interaction of the PZP domain of BRPF1 with the nucleosome impacts chromatin dynamics and acetylation. Nucleic Acids Res. 2016 Jan 08; 44(1):472-84. PMID: 26626149; PMCID: PMC4705663.
    4. Muthurajan UM, Hepler MR, Hieb AR, Clark NJ, Kramer M, Yao T, Luger K. Automodification switches PARP-1 function from chromatin architectural protein to histone chaperone. Proc Natl Acad Sci U S A. 2014 Sep 02; 111(35):12752-7. PMID: 25136112; PMCID: PMC4156740.
    5. Yelagandula R, Stroud H, Holec S, Zhou K, Feng S, Zhong X, Muthurajan UM, Nie X, Kawashima T, Groth M, Luger K, Jacobsen SE, Berger F. The histone variant H2A.W defines heterochromatin and promotes chromatin condensation in Arabidopsis. Cell. 2014 Jul 03; 158(1):98-109. PMID: 24995981; PMCID: PMC4671829.
    6. Chodaparambil JV, Pate KT, Hepler MR, Tsai BP, Muthurajan UM, Luger K, Waterman ML, Weis WI. Molecular functions of the TLE tetramerization domain in Wnt target gene repression. EMBO J. 2014 Apr 01; 33(7):719-31. PMID: 24596249; PMCID: PMC4000089.
    7. Rogge RA, Kalashnikova AA, Muthurajan UM, Porter-Goff ME, Luger K, Hansen JC. Assembly of nucleosomal arrays from recombinant core histones and nucleosome positioning DNA. J Vis Exp. 2013 Sep 10; (79). PMID: 24056546; PMCID: PMC3864267.
    8. Kalashnikova AA, Porter-Goff ME, Muthurajan UM, Luger K, Hansen JC. The role of the nucleosome acidic patch in modulating higher order chromatin structure. J R Soc Interface. 2013 May 06; 10(82):20121022. PMID: 23446052; PMCID: PMC3627075.
    9. Clark NJ, Kramer M, Muthurajan UM, Luger K. Alternative modes of binding of poly(ADP-ribose) polymerase 1 to free DNA and nucleosomes. J Biol Chem. 2012 Sep 21; 287(39):32430-9. PMID: 22854955; PMCID: PMC3463355.
    10. Winkler DD, Muthurajan UM, Hieb AR, Luger K. Histone chaperone FACT coordinates nucleosome interaction through multiple synergistic binding events. J Biol Chem. 2011 Dec 02; 286(48):41883-92. PMID: 21969370; PMCID: PMC3308894.
    11. Muthurajan UM, McBryant SJ, Lu X, Hansen JC, Luger K. The linker region of macroH2A promotes self-association of nucleosomal arrays. J Biol Chem. 2011 Jul 08; 286(27):23852-64. PMID: 21532035; PMCID: PMC3129167.
    12. Yang C, van der Woerd MJ, Muthurajan UM, Hansen JC, Luger K. Biophysical analysis and small-angle X-ray scattering-derived structures of MeCP2-nucleosome complexes. Nucleic Acids Res. 2011 May; 39(10):4122-35. PMID: 21278419; PMCID: PMC3105411.
    13. Pujari V, Radebaugh CA, Chodaparambil JV, Muthurajan UM, Almeida AR, Fischbeck JA, Luger K, Stargell LA. The transcription factor Spn1 regulates gene expression via a highly conserved novel structural motif. J Mol Biol. 2010 Nov 19; 404(1):1-15. PMID: 20875428; PMCID: PMC2993574.
    14. Sekiya T, Muthurajan UM, Luger K, Tulin AV, Zaret KS. Nucleosome-binding affinity as a primary determinant of the nuclear mobility of the pioneer transcription factor FoxA. Genes Dev. 2009 Apr 01; 23(7):804-9. PMID: 19339686; PMCID: PMC2666343.
    15. Muthurajan UM, Bao Y, Forsberg LJ, Edayathumangalam RS, Dyer PN, White CL, Luger K. Crystal structures of histone Sin mutant nucleosomes reveal altered protein-DNA interactions. EMBO J. 2004 Jan 28; 23(2):260-71. PMID: 14739929; PMCID: PMC1271754.
    16. Dyer PN, Edayathumangalam RS, White CL, Bao Y, Chakravarthy S, Muthurajan UM, Luger K. Reconstitution of nucleosome core particles from recombinant histones and DNA. Methods Enzymol. 2004; 375:23-44. PMID: 14870657.
      View in: PubMed
    17. Muthurajan UM, Park YJ, Edayathumangalam RS, Suto RK, Chakravarthy S, Dyer PN, Luger K. Structure and dynamics of nucleosomal DNA. Biopolymers. 2003 Apr; 68(4):547-56. PMID: 12666179.
      View in: PubMed
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