Tyrosine kinase inhibition in leukemia induces an altered metabolic state sensitive to mitochondrial perturbations.
Alvarez-Calderon F, Gregory MA, Pham-Danis C, DeRyckere D, Stevens BM, Zaberezhnyy V, Hill AA, Gemta L, Kumar A, Kumar V, Wempe MF, Pollyea DA, Jordan CT, Serkova NJ, Graham DK, DeGregori J. Tyrosine kinase inhibition in leukemia induces an altered metabolic state sensitive to mitochondrial perturbations. Clin Cancer Res. 2015 Mar 15; 21(6):1360-72.
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Animals
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Antineoplastic Combined Chemotherapy Protocols
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Apoptosis
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Cell Line, Tumor
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Dihydrolipoyllysine-Residue Acetyltransferase
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Disease Models, Animal
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Female
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fms-Like Tyrosine Kinase 3
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Fusion Proteins, bcr-abl
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Humans
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Imatinib Mesylate
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Ketone Oxidoreductases
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive
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Membrane Potential, Mitochondrial
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Mice
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Mice, Inbred C57BL
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Mice, Inbred NOD
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Mice, Knockout
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Mitochondria
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Mitochondrial Proteins
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Mitochondrial Proton-Translocating ATPases
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Oligomycins
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Protein Kinase Inhibitors
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Protein-Tyrosine Kinases
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RNA Interference
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RNA, Small Interfering
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Superoxides