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Yubin Miao

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-RAD General Operations
Phone303/724-3763

    Collapse Biography 
    Collapse awards and honors
    2002Society of Nuclear Medicine Radiopharmaceutical Science Council Young Investigator Award
    2007American Association of Colleges of Pharmacy New Investigator Award
    2008Department of Defense Breast Cancer Research Program Idea Award
    2014STC.UNM Innovation Award
    2019The Academy for Radiology & Biomedical Imaging Research Distinguished Investigator Award

    Collapse Research 
    Collapse research activities and funding
    R01CA225837     (MIAO, YUBIN)Apr 1, 2018 - Mar 31, 2023
    NIH
    Novel Receptor-Targeting Peptides for Melanoma Therapy
    Role: Principal Investigator
    R01DK112260     (MELANSON, EDWARD L)Sep 16, 2016 - Aug 31, 2021
    NIH
    The impact of estrogen status on the biological function of brown adipose tissue in women measured using quantitative PET/CT
    Role: Co-Investigator
    R15CA173516     (MIAO, YUBIN)Aug 1, 2013 - Jul 31, 2016
    NIH/NCI
    Novel Receptor-Targeting Theranostic Peptides for Prostate Cancer
    Role: Principal Investigator
    P20RR016480     (ARTERBURN, JEFFREY)May 1, 2009 - Feb 28, 2014
    NIH/NCRR
    New Mexico IDeA Networks of Biomedical Research Excellence (INBRE)
    Role: Project Investigator
    W81XWH-09-1-0105     (MIAO, YUBIN)Jan 1, 2009 - Jan 31, 2012
    DOD
    Novel Radiolabeled Peptides Targeting Gonadotropin-releasing Hormone Receptors for Non-invasive Breast Cancer Imaging
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Qiao Z, Xu J, Gonzalez R, Miao Y. Novel Al18F-NOTA-Conjugated Lactam-Cyclized a-Melanocyte-Stimulating Hormone Peptides with Enhanced Melanoma Uptake. Bioconjug Chem. 2022 05 18; 33(5):982-990. PMID: 35475603.
      View in: PubMed
    2. Bernardes E, Caravan P, van Dam RM, Deuther-Conrad W, Ellis B, Furumoto S, Guillet B, Huang YY, Jia H, Laverman P, Li Z, Liu Z, Lodi F, Miao Y, Perk L, Schirrmacher R, Vercoullie J, Yang H, Yang M, Yang X, Zhang J, Zhang MR, Zhu H. Highlight selection of radiochemistry and radiopharmacy developments by editorial board. EJNMMI Radiopharm Chem. 2022 Apr 26; 7(1):9. PMID: 35471681.
      View in: PubMed
    3. Miao Y, Quinn TP. Advances in Receptor-Targeted Radiolabeled Peptides for Melanoma Imaging and Therapy. J Nucl Med. 2021 03; 62(3):313-318. PMID: 33277401.
      View in: PubMed
    4. Xu J, Qiao Z, Gonzalez R, Miao Y. Facile preparation of a novel Ga-67-labeled NODAGA-conjugated lactam-cyclized alpha-MSH peptide at room temperature for melanoma targeting. Bioorg Med Chem Lett. 2020 12 15; 30(24):127627. PMID: 33141072.
      View in: PubMed
    5. Qiao Z, Xu J, Gonzalez R, Miao Y. Novel [99mTc]-Tricarbonyl-NOTA-Conjugated Lactam-Cyclized Alpha-MSH Peptide with Enhanced Melanoma Uptake and Reduced Renal Uptake. Mol Pharm. 2020 09 08; 17(9):3581-3588. PMID: 32663011.
      View in: PubMed
    6. Xu J, Yang J, Gonzalez R, Fisher DR, Miao Y. Melanoma-Targeting Property of Y-90-Labeled Lactam-Cyclized a-Melanocyte-Stimulating Hormone Peptide. Cancer Biother Radiopharm. 2019 Nov; 34(9):597-603. PMID: 31644317.
      View in: PubMed
    7. Yang J, Xu J, Gonzalez R, Lindner T, Kratochwil C, Miao Y. 68Ga-DOTA-GGNle-CycMSHhex targets the melanocortin-1 receptor for melanoma imaging. Sci Transl Med. 2018 11 07; 10(466). PMID: 30404861.
      View in: PubMed
    8. Li J, Zheng H, Wang W, Miao Y, Sheng Y, Feng C. Role of an isoform-specific residue at the calmodulin-heme (NO synthase) interface in the FMN - heme electron transfer. FEBS Lett. 2018 07; 592(14):2425-2431. PMID: 29904908.
      View in: PubMed
    9. Bandara N, Stott Reynolds TJ, Schehr R, Bandari RP, Diebolder PJ, Krieger S, Xu J, Miao Y, Rogers BE, Smith CJ. Matched-pair, 86Y/90Y-labeled, bivalent RGD/bombesin antagonist, [RGD-Glu-[DO3A]-6-Ahx-RM2], as a potential theranostic agent for prostate cancer. Nucl Med Biol. 2018 Jul - Aug; 62-63:71-77. PMID: 29929115.
      View in: PubMed
    10. Berman BD, Pollard RT, Shelton E, Karki R, Smith-Jones PM, Miao Y. GABAA Receptor Availability Changes Underlie Symptoms in Isolated Cervical Dystonia. Front Neurol. 2018; 9:188. PMID: 29670567.
      View in: PubMed
    11. Liu L, Xu J, Yang J, Feng C, Miao Y. Metastatic melanoma imaging using a novel Tc-99m-labeled lactam-cyclized alpha-MSH peptide. Bioorg Med Chem Lett. 2017 11 15; 27(22):4952-4955. PMID: 29054361.
      View in: PubMed
    12. Liu L, Xu J, Yang J, Feng C, Miao Y. Imaging human melanoma using a novel Tc-99m-labeled lactam bridge-cyclized alpha-MSH peptide. Bioorg Med Chem Lett. 2016 10 01; 26(19):4724-4728. PMID: 27568083.
      View in: PubMed
    13. Jiang Z, Bandari RP, Reynolds TJ, Xu J, Miao Y, Rold TL, Szczodroski AF, Jurisson SS, Smith CJ. Molecular imaging investigations of a 67Ga/64Cu labeled bivalent ligand, [RGD-Glu-(DO3A)-6-Ahx-RM2], targeting GRPR/avß3 biomarkers: a comparative study. Radiochimica Acta. 2016; 104:499-512.
      View Publication
    14. Wu Z, Hu CA, Wu G, Zhaorigetu S, Chand H, Sun K, Ji Y, Wang B, Dai Z, Walton B, Miao Y, Hou Y. Intimacy and a deadly feud: the interplay of autophagy and apoptosis mediated by amino acids. Amino Acids. 2015 Oct; 47(10):2089-99. PMID: 26354329.
      View in: PubMed
    15. Xu J, Yang J, Miao Y. Dual receptor-targeting ??mTc-labeled Arg-Gly-Asp-conjugated Alpha-Melanocyte stimulating hormone hybrid peptides for human melanoma imaging. Nucl Med Biol. 2015 Apr; 42(4):369-74. PMID: 25577037.
      View in: PubMed
    16. Guo H, Miao Y. Introduction of an 8-aminooctanoic acid linker enhances uptake of 99mTc-labeled lactam bridge-cyclized a-MSH peptide in melanoma. J Nucl Med. 2014 Dec; 55(12):2057-63. PMID: 25453052.
      View in: PubMed
    17. Stott Reynolds TJ, Schehr R, Liu D, Xu J, Miao Y, Hoffman TJ, Rold TL, Lewis MR, Smith CJ. Characterization and evaluation of DOTA-conjugated Bombesin/RGD-antagonists for prostate cancer tumor imaging and therapy. Nucl Med Biol. 2015 Feb; 42(2):99-108. PMID: 25459113.
      View in: PubMed
    18. Durkan K, Jiang Z, Rold TL, Sieckman GL, Hoffman TJ, Bandari RP, Szczodroski AF, Liu L, Miao Y, Reynolds TS, Smith CJ. A heterodimeric [RGD-Glu-[(64)Cu-NO2A]-6-Ahx-RM2] avß3/GRPr-targeting antagonist radiotracer for PET imaging of prostate tumors. Nucl Med Biol. 2014 Feb; 41(2):133-9. PMID: 24480266.
      View in: PubMed
    19. Yang J, Flook AM, Feng C, Miao Y. Linker modification reduced the renal uptake of technetium-99m-labeled Arg-Ala-Asp-conjugated alpha-melanocyte stimulating hormone peptide. Bioorg Med Chem Lett. 2014 Jan 01; 24(1):195-8. PMID: 24316121.
      View in: PubMed
    20. Flook AM, Yang J, Miao Y. Effects of amino acids on melanoma targeting and clearance properties of Tc-99m-labeled Arg-X-Asp-conjugated a-melanocyte stimulating hormone peptides. J Med Chem. 2013 Nov 14; 56(21):8793-802. PMID: 24131154.
      View in: PubMed
    21. Yang J, Liu L, Miao Y. Effects of the Arg-Pro and Gly-Gly-Nle Moieties on Melanocortin-1 Receptor Binding Affinities of a-MSH Peptides. ACS Med Chem Lett. 2013 Oct 10; 4(10). PMID: 24349641.
      View in: PubMed
    22. Guo H, Hathaway H, Royce ME, Prossnitz ER, Miao Y. Influences of hydrocarbon linkers on the receptor binding affinities of gonadotropin-releasing hormone peptides. Bioorg Med Chem Lett. 2013 Oct 15; 23(20):5484-7. PMID: 24018188.
      View in: PubMed
    23. Flook AM, Yang J, Miao Y. Evaluation of new Tc-99m-labeled Arg-X-Asp-conjugated a-melanocyte stimulating hormone peptides for melanoma imaging. Mol Pharm. 2013 Sep 03; 10(9):3417-24. PMID: 23885640.
      View in: PubMed
    24. Guo H, Gallazzi F, Miao Y. Design and evaluation of new Tc-99m-labeled lactam bridge-cyclized alpha-MSH peptides for melanoma imaging. Mol Pharm. 2013 Apr 01; 10(4):1400-8. PMID: 23418722.
      View in: PubMed
    25. Guo H, Miao Y. Melanoma targeting property of a Lu-177-labeled lactam bridge-cyclized alpha-MSH peptide. Bioorg Med Chem Lett. 2013 Apr 15; 23(8):2319-23. PMID: 23473679.
      View in: PubMed
    26. Guo H, Miao Y. Cu-64-labeled lactam bridge-cyclized a-MSH peptides for PET imaging of melanoma. Mol Pharm. 2012 Aug 06; 9(8):2322-30. PMID: 22780870.
      View in: PubMed
    27. Guo H, Gallazzi F, Miao Y. Gallium-67-labeled lactam bridge-cyclized alpha-MSH peptides with enhanced melanoma uptake and reduced renal uptake. Bioconjug Chem. 2012 Jun 20; 23(6):1341-8. PMID: 22621181.
      View in: PubMed
    28. Guo H, Gallazzi F, Sklar LA, Miao Y. A novel indium-111-labeled gonadotropin-releasing hormone peptide for human prostate cancer imaging. Bioorg Med Chem Lett. 2011 Sep 15; 21(18):5184-7. PMID: 21821417.
      View in: PubMed
    29. Guo H, Lu J, Hathaway H, Royce ME, Prossnitz ER, Miao Y. Synthesis and evaluation of novel gonadotropin-releasing hormone receptor-targeting peptides. Bioconjug Chem. 2011 Aug 17; 22(8):1682-9. PMID: 21749045.
      View in: PubMed
    30. Quinn T, Zhang X, Miao Y. Targeted melanoma imaging and therapy with radiolabeled alpha-melanocyte stimulating hormone peptide analogues. G Ital Dermatol Venereol. 2010 Apr; 145(2):245-58. PMID: 20467398.
      View in: PubMed
    31. Guo H, Yang J, Gallazzi F, Miao Y. Reduction of the ring size of radiolabeled lactam bridge-cyclized alpha-MSH peptide, resulting in enhanced melanoma uptake. J Nucl Med. 2010 Mar; 51(3):418-26. PMID: 20150256.
      View in: PubMed
    32. Guo H, Yang J, Shenoy N, Miao Y. Gallium-67-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone peptide for primary and metastatic melanoma imaging. Bioconjug Chem. 2009 Dec; 20(12):2356-63. PMID: 19919057.
      View in: PubMed
    33. Guo H, Shenoy N, Gershman BM, Yang J, Sklar LA, Miao Y. Metastatic melanoma imaging with an (111)In-labeled lactam bridge-cyclized alpha-melanocyte-stimulating hormone peptide. Nucl Med Biol. 2009 Apr; 36(3):267-76. PMID: 19324272.
      View in: PubMed
    34. Wei L, Zhang X, Gallazzi F, Miao Y, Jin X, Brechbiel MW, Xu H, Clifford T, Welch MJ, Lewis JS, Quinn TP. Melanoma imaging using (111)In-, (86)Y- and (68)Ga-labeled CHX-A''-Re(Arg11)CCMSH. Nucl Med Biol. 2009 May; 36(4):345-54. PMID: 19423001.
      View in: PubMed
    35. Miao Y, Figueroa SD, Fisher DR, Moore HA, Testa RF, Hoffman TJ, Quinn TP. 203Pb-labeled alpha-melanocyte-stimulating hormone peptide as an imaging probe for melanoma detection. J Nucl Med. 2008 May; 49(5):823-9. PMID: 18413404.
      View in: PubMed
    36. Miao Y, Quinn TP. Peptide-targeted radionuclide therapy for melanoma. Crit Rev Oncol Hematol. 2008 Sep; 67(3):213-28. PMID: 18387816.
      View in: PubMed
    37. Wei L, Miao Y, Gallazzi F, Quinn TP, Welch MJ, Vavere AL, Lewis JS. Gallium-68-labeled DOTA-rhenium-cyclized alpha-melanocyte-stimulating hormone analog for imaging of malignant melanoma. Nucl Med Biol. 2007 Nov; 34(8):945-53. PMID: 17998097.
      View in: PubMed
    38. Miao Y, Shelton T, Quinn TP. Therapeutic efficacy of a 177Lu-labeled DOTA conjugated alpha-melanocyte-stimulating hormone peptide in a murine melanoma-bearing mouse model. Cancer Biother Radiopharm. 2007 Jun; 22(3):333-41. PMID: 17651039.
      View in: PubMed
    39. Miao Y, Quinn TP. Alpha-melanocyte stimulating hormone peptide-targeted melanoma imaging. Front Biosci. 2007 May 01; 12:4514-24. PMID: 17485393.
      View in: PubMed
    40. Newton JR, Miao Y, Deutscher SL, Quinn TP. Melanoma imaging with pretargeted bivalent bacteriophage. J Nucl Med. 2007 Mar; 48(3):429-36. PMID: 17332621.
      View in: PubMed
    41. Miao Y, Benwell K, Quinn TP. 99mTc- and 111In-labeled alpha-melanocyte-stimulating hormone peptides as imaging probes for primary and pulmonary metastatic melanoma detection. J Nucl Med. 2007 Jan; 48(1):73-80. PMID: 17204701.
      View in: PubMed
    42. Wei L, Butcher C, Miao Y, Gallazzi F, Quinn TP, Welch MJ, Lewis JS. Synthesis and biologic evaluation of 64Cu-labeled rhenium-cyclized alpha-MSH peptide analog using a cross-bridged cyclam chelator. J Nucl Med. 2007 Jan; 48(1):64-72. PMID: 17204700.
      View in: PubMed
    43. Miao Y, Hylarides M, Fisher DR, Shelton T, Moore H, Wester DW, Fritzberg AR, Winkelmann CT, Hoffman T, Quinn TP. Melanoma therapy via peptide-targeted {alpha}-radiation. Clin Cancer Res. 2005 Aug 01; 11(15):5616-21. PMID: 16061880.
      View in: PubMed
    44. Miao Y, Owen NK, Fisher DR, Hoffman TJ, Quinn TP. Therapeutic efficacy of a 188Re-labeled alpha-melanocyte-stimulating hormone peptide analog in murine and human melanoma-bearing mouse models. J Nucl Med. 2005 Jan; 46(1):121-9. PMID: 15632042.
      View in: PubMed
    45. Miao Y, Owen NK, Whitener D, Gallazzi F, Hoffman TJ, Quinn TP. In vivo evaluation of 188Re-labeled alpha-melanocyte stimulating hormone peptide analogs for melanoma therapy. Int J Cancer. 2002 Oct 10; 101(5):480-7. PMID: 12216078.
      View in: PubMed
    46. Cheng Z, Chen J, Miao Y, Owen NK, Quinn TP, Jurisson SS. Modification of the structure of a metallopeptide: synthesis and biological evaluation of (111)In-labeled DOTA-conjugated rhenium-cyclized alpha-MSH analogues. J Med Chem. 2002 Jul 04; 45(14):3048-56. PMID: 12086490.
      View in: PubMed
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