Yubin Miao
Title | Professor |
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Institution | University of Colorado Denver - Anschutz Medical Campus |
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Department | SOM-RAD General Operations |
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Phone | 303/724-3763 |
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Biography 2002 | Society of Nuclear Medicine Radiopharmaceutical Science Council Young Investigator Award | 2007 | American Association of Colleges of Pharmacy New Investigator Award | 2008 | Department of Defense Breast Cancer Research Program Idea Award | 2014 | STC.UNM Innovation Award | 2019 | The Academy for Radiology & Biomedical Imaging Research Distinguished Investigator Award |
Research W81XWH-09-1-0105 (MIAO, YUBIN)Jan 1, 2009 - Jan 31, 2012 DOD Novel Radiolabeled Peptides Targeting Gonadotropin-releasing Hormone Receptors for Non-invasive Breast Cancer Imaging Role: Principal Investigator |
| P20RR016480 (ARTERBURN, JEFFREY)May 1, 2009 - Feb 28, 2014 NIH/NCRR New Mexico IDeA Networks of Biomedical Research Excellence (INBRE) Role: Project Investigator |
| R15CA173516 (MIAO, YUBIN)Aug 1, 2013 - Jul 31, 2016 NIH/NCI Novel Receptor-Targeting Theranostic Peptides for Prostate Cancer Role: Principal Investigator |
| R01DK112260 (MELANSON, EDWARD L)Sep 16, 2016 - Aug 31, 2021 NIH The impact of estrogen status on the biological function of brown adipose tissue in women measured using quantitative PET/CT Role: Co-Investigator |
| R01CA225837 (MIAO, YUBIN)Apr 1, 2018 - Mar 31, 2023 NIH Novel Receptor-Targeting Peptides for Melanoma Therapy Role: Principal Investigator |
Bibliographic
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Miao Y, Quinn TP. Advances in Receptor-Targeted Radiolabeled Peptides for Melanoma Imaging and Therapy. J Nucl Med. 2021 Mar; 62(3):313-318. PMID: 33277401.
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Xu J, Qiao Z, Gonzalez R, Miao Y. Facile preparation of a novel Ga-67-labeled NODAGA-conjugated lactam-cyclized alpha-MSH peptide at room temperature for melanoma targeting. Bioorg Med Chem Lett. 2020 12 15; 30(24):127627. PMID: 33141072.
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Qiao Z, Xu J, Gonzalez R, Miao Y. Novel [99mTc]-Tricarbonyl-NOTA-Conjugated Lactam-Cyclized Alpha-MSH Peptide with Enhanced Melanoma Uptake and Reduced Renal Uptake. Mol Pharm. 2020 09 08; 17(9):3581-3588. PMID: 32663011.
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Xu J, Yang J, Gonzalez R, Fisher DR, Miao Y. Melanoma-Targeting Property of Y-90-Labeled Lactam-Cyclized a-Melanocyte-Stimulating Hormone Peptide. Cancer Biother Radiopharm. 2019 Nov; 34(9):597-603. PMID: 31644317.
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Yang J, Xu J, Cheuy L, Gonzalez R, Fisher DR, Miao Y. Evaluation of a Novel Pb-203-Labeled Lactam-Cyclized Alpha-Melanocyte-Stimulating Hormone Peptide for Melanoma Targeting. Mol Pharm. 2019 04 01; 16(4):1694-1702. PMID: 30763112.
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Yang J, Xu J, Gonzalez R, Lindner T, Kratochwil C, Miao Y. 68Ga-DOTA-GGNle-CycMSHhex targets the melanocortin-1 receptor for melanoma imaging. Sci Transl Med. 2018 11 07; 10(466). PMID: 30404861.
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Li J, Zheng H, Wang W, Miao Y, Sheng Y, Feng C. Role of an isoform-specific residue at the calmodulin-heme (NO synthase) interface in the FMN - heme electron transfer. FEBS Lett. 2018 07; 592(14):2425-2431. PMID: 29904908.
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Bandara N, Stott Reynolds TJ, Schehr R, Bandari RP, Diebolder PJ, Krieger S, Xu J, Miao Y, Rogers BE, Smith CJ. Matched-pair, 86Y/90Y-labeled, bivalent RGD/bombesin antagonist, [RGD-Glu-[DO3A]-6-Ahx-RM2], as a potential theranostic agent for prostate cancer. Nucl Med Biol. 2018 Jul - Aug; 62-63:71-77. PMID: 29929115.
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Berman BD, Pollard RT, Shelton E, Karki R, Smith-Jones PM, Miao Y. GABAA Receptor Availability Changes Underlie Symptoms in Isolated Cervical Dystonia. Front Neurol. 2018; 9:188. PMID: 29670567.
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Astashkin AV, Li J, Zheng H, Miao Y, Feng C. A docked state conformational dynamics model to explain the ionic strength dependence of FMN - heme electron transfer in nitric oxide synthase. J Inorg Biochem. 2018 07; 184:146-155. PMID: 29751215.
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Liu L, Xu J, Yang J, Feng C, Miao Y. Metastatic melanoma imaging using a novel Tc-99m-labeled lactam-cyclized alpha-MSH peptide. Bioorg Med Chem Lett. 2017 11 15; 27(22):4952-4955. PMID: 29054361.
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Xu J, Feng C, Miao Y. Evaluation of novel 111In-labeled gonadotropin-releasing hormone peptides for human prostate cancer imaging. Bioorg Med Chem Lett. 2017 10 15; 27(20):4647-4651. PMID: 28917649.
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Chen L, Zheng H, Li W, Li W, Miao Y, Feng C. Role of a Conserved Tyrosine Residue in the FMN-Heme Interdomain Electron Transfer in Inducible Nitric Oxide Synthase. J Phys Chem A. 2016 Oct 06; 120(39):7610-7616. PMID: 27633182.
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Liu L, Xu J, Yang J, Feng C, Miao Y. Imaging human melanoma using a novel Tc-99m-labeled lactam bridge-cyclized alpha-MSH peptide. Bioorg Med Chem Lett. 2016 10 01; 26(19):4724-4728. PMID: 27568083.
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Jiang Z, Bandari RP, Reynolds TJ, Xu J, Miao Y, Rold TL, Szczodroski AF, Jurisson SS, Smith CJ. Molecular imaging investigations of a 67Ga/64Cu labeled bivalent ligand, [RGD-Glu-(DO3A)-6-Ahx-RM2], targeting GRPR/avß3 biomarkers: a comparative study. Radiochimica Acta. 2016; 104:499-512.
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Wu Z, Hu CA, Wu G, Zhaorigetu S, Chand H, Sun K, Ji Y, Wang B, Dai Z, Walton B, Miao Y, Hou Y. Intimacy and a deadly feud: the interplay of autophagy and apoptosis mediated by amino acids. Amino Acids. 2015 Oct; 47(10):2089-99. PMID: 26354329.
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Astashkin AV, Chen L, Elmore BO, Kunwar D, Miao Y, Li H, Poulos TL, Roman LJ, Feng C. Probing the Hydrogen Bonding of the Ferrous-NO Heme Center of nNOS by Pulsed Electron Paramagnetic Resonance. J Phys Chem A. 2015 Jun 25; 119(25):6641-9. PMID: 26035438.
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Yang J, Hu CA, Miao Y. Tc-99m-labeled RGD-conjugated alpha-melanocyte stimulating hormone hybrid peptides with reduced renal uptake. Amino Acids. 2015 Apr; 47(4):813-23. PMID: 25557051.
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Xu J, Yang J, Miao Y. Dual receptor-targeting ??mTc-labeled Arg-Gly-Asp-conjugated Alpha-Melanocyte stimulating hormone hybrid peptides for human melanoma imaging. Nucl Med Biol. 2015 Apr; 42(4):369-74. PMID: 25577037.
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Guo H, Miao Y. Introduction of an 8-aminooctanoic acid linker enhances uptake of 99mTc-labeled lactam bridge-cyclized a-MSH peptide in melanoma. J Nucl Med. 2014 Dec; 55(12):2057-63. PMID: 25453052.
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Flook AM, Yang J, Miao Y. Substitution of the Lys linker with the ß-Ala linker dramatically decreased the renal uptake of 99mTc-labeled Arg-X-Asp-conjugated and X-Ala-Asp-conjugated a-melanocyte stimulating hormone peptides. J Med Chem. 2014 Nov 13; 57(21):9010-8. PMID: 25290883.
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Stott Reynolds TJ, Schehr R, Liu D, Xu J, Miao Y, Hoffman TJ, Rold TL, Lewis MR, Smith CJ. Characterization and evaluation of DOTA-conjugated Bombesin/RGD-antagonists for prostate cancer tumor imaging and therapy. Nucl Med Biol. 2015 Feb; 42(2):99-108. PMID: 25459113.
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Lu J, Hathaway HJ, Royce ME, Prossnitz ER, Miao Y. Introduction of D-phenylalanine enhanced the receptor binding affinities of gonadotropin-releasing hormone peptides. Bioorg Med Chem Lett. 2014 Feb 01; 24(3):725-30. PMID: 24418777.
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Durkan K, Jiang Z, Rold TL, Sieckman GL, Hoffman TJ, Bandari RP, Szczodroski AF, Liu L, Miao Y, Reynolds TS, Smith CJ. A heterodimeric [RGD-Glu-[(64)Cu-NO2A]-6-Ahx-RM2] avß3/GRPr-targeting antagonist radiotracer for PET imaging of prostate tumors. Nucl Med Biol. 2014 Feb; 41(2):133-9. PMID: 24480266.
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Yang J, Flook AM, Feng C, Miao Y. Linker modification reduced the renal uptake of technetium-99m-labeled Arg-Ala-Asp-conjugated alpha-melanocyte stimulating hormone peptide. Bioorg Med Chem Lett. 2014 Jan 01; 24(1):195-8. PMID: 24316121.
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Flook AM, Yang J, Miao Y. Effects of amino acids on melanoma targeting and clearance properties of Tc-99m-labeled Arg-X-Asp-conjugated a-melanocyte stimulating hormone peptides. J Med Chem. 2013 Nov 14; 56(21):8793-802. PMID: 24131154.
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Yang J, Liu L, Miao Y. Effects of the Arg-Pro and Gly-Gly-Nle Moieties on Melanocortin-1 Receptor Binding Affinities of a-MSH Peptides. ACS Med Chem Lett. 2013 Oct 10; 4(10). PMID: 24349641.
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Guo H, Hathaway H, Royce ME, Prossnitz ER, Miao Y. Influences of hydrocarbon linkers on the receptor binding affinities of gonadotropin-releasing hormone peptides. Bioorg Med Chem Lett. 2013 Oct 15; 23(20):5484-7. PMID: 24018188.
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Flook AM, Yang J, Miao Y. Evaluation of new Tc-99m-labeled Arg-X-Asp-conjugated a-melanocyte stimulating hormone peptides for melanoma imaging. Mol Pharm. 2013 Sep 03; 10(9):3417-24. PMID: 23885640.
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Guo H, Gallazzi F, Miao Y. Design and evaluation of new Tc-99m-labeled lactam bridge-cyclized alpha-MSH peptides for melanoma imaging. Mol Pharm. 2013 Apr 01; 10(4):1400-8. PMID: 23418722.
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Guo H, Miao Y. Melanoma targeting property of a Lu-177-labeled lactam bridge-cyclized alpha-MSH peptide. Bioorg Med Chem Lett. 2013 Apr 15; 23(8):2319-23. PMID: 23473679.
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Guo H, Miao Y. Cu-64-labeled lactam bridge-cyclized a-MSH peptides for PET imaging of melanoma. Mol Pharm. 2012 Aug 06; 9(8):2322-30. PMID: 22780870.
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Guo H, Gallazzi F, Miao Y. Gallium-67-labeled lactam bridge-cyclized alpha-MSH peptides with enhanced melanoma uptake and reduced renal uptake. Bioconjug Chem. 2012 Jun 20; 23(6):1341-8. PMID: 22621181.
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Yang J, Lu J, Miao Y. Structural modification on the Lys linker enhanced tumor to kidney uptake ratios of 99mTc-labeled RGD-conjugated a-MSH hybrid peptides. Mol Pharm. 2012 May 07; 9(5):1418-24. PMID: 22452443.
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Yang J, Miao Y. Substitution of Gly with Ala enhanced the melanoma uptake of technetium-99m-labeled Arg-Ala-Asp-conjugated alpha-melanocyte stimulating hormone peptide. Bioorg Med Chem Lett. 2012 Feb 15; 22(4):1541-5. PMID: 22297112.
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Guo H, Gallazzi F, Sklar LA, Miao Y. A novel indium-111-labeled gonadotropin-releasing hormone peptide for human prostate cancer imaging. Bioorg Med Chem Lett. 2011 Sep 15; 21(18):5184-7. PMID: 21821417.
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Guo H, Lu J, Hathaway H, Royce ME, Prossnitz ER, Miao Y. Synthesis and evaluation of novel gonadotropin-releasing hormone receptor-targeting peptides. Bioconjug Chem. 2011 Aug 17; 22(8):1682-9. PMID: 21749045.
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Guo H, Yang J, Gallazzi F, Miao Y. Effects of the amino acid linkers on the melanoma-targeting and pharmacokinetic properties of 111In-labeled lactam bridge-cyclized alpha-MSH peptides. J Nucl Med. 2011 Apr; 52(4):608-16. PMID: 21421725.
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Yang J, Guo H, Padilla RS, Berwick M, Miao Y. Replacement of the Lys linker with an Arg linker resulting in improved melanoma uptake and reduced renal uptake of Tc-99m-labeled Arg-Gly-Asp-conjugated alpha-melanocyte stimulating hormone hybrid peptide. Bioorg Med Chem. 2010 Sep 15; 18(18):6695-700. PMID: 20728365.
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Yang J, Guo H, Miao Y. Technetium-99m-labeled Arg-Gly-Asp-conjugated alpha-melanocyte stimulating hormone hybrid peptides for human melanoma imaging. Nucl Med Biol. 2010 Nov; 37(8):873-83. PMID: 21055617.
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Quinn T, Zhang X, Miao Y. Targeted melanoma imaging and therapy with radiolabeled alpha-melanocyte stimulating hormone peptide analogues. G Ital Dermatol Venereol. 2010 Apr; 145(2):245-58. PMID: 20467398.
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Guo H, Yang J, Gallazzi F, Miao Y. Reduction of the ring size of radiolabeled lactam bridge-cyclized alpha-MSH peptide, resulting in enhanced melanoma uptake. J Nucl Med. 2010 Mar; 51(3):418-26. PMID: 20150256.
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Guo H, Yang J, Shenoy N, Miao Y. Gallium-67-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone peptide for primary and metastatic melanoma imaging. Bioconjug Chem. 2009 Dec; 20(12):2356-63. PMID: 19919057.
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Guo H, Yang J, Gallazzi F, Prossnitz ER, Sklar LA, Miao Y. Effect of DOTA position on melanoma targeting and pharmacokinetic properties of 111In-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone peptide. Bioconjug Chem. 2009 Nov; 20(11):2162-8. PMID: 19817405.
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Yang J, Guo H, Gallazzi F, Berwick M, Padilla RS, Miao Y. Evaluation of a novel Arg-Gly-Asp-conjugated a-melanocyte stimulating hormone hybrid peptide for potential melanoma therapy. Bioconjug Chem. 2009 Aug 19; 20(8):1634-42. PMID: 19552406.
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Guo H, Shenoy N, Gershman BM, Yang J, Sklar LA, Miao Y. Metastatic melanoma imaging with an (111)In-labeled lactam bridge-cyclized alpha-melanocyte-stimulating hormone peptide. Nucl Med Biol. 2009 Apr; 36(3):267-76. PMID: 19324272.
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Wei L, Zhang X, Gallazzi F, Miao Y, Jin X, Brechbiel MW, Xu H, Clifford T, Welch MJ, Lewis JS, Quinn TP. Melanoma imaging using (111)In-, (86)Y- and (68)Ga-labeled CHX-A''-Re(Arg11)CCMSH. Nucl Med Biol. 2009 May; 36(4):345-54. PMID: 19423001.
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Miao Y, Figueroa SD, Fisher DR, Moore HA, Testa RF, Hoffman TJ, Quinn TP. 203Pb-labeled alpha-melanocyte-stimulating hormone peptide as an imaging probe for melanoma detection. J Nucl Med. 2008 May; 49(5):823-9. PMID: 18413404.
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Miao Y, Quinn TP. Peptide-targeted radionuclide therapy for melanoma. Crit Rev Oncol Hematol. 2008 Sep; 67(3):213-28. PMID: 18387816.
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Miao Y, Gallazzi F, Guo H, Quinn TP. 111In-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone peptide analogues for melanoma imaging. Bioconjug Chem. 2008 Feb; 19(2):539-47. PMID: 18197608.
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Wei L, Miao Y, Gallazzi F, Quinn TP, Welch MJ, Vavere AL, Lewis JS. Gallium-68-labeled DOTA-rhenium-cyclized alpha-melanocyte-stimulating hormone analog for imaging of malignant melanoma. Nucl Med Biol. 2007 Nov; 34(8):945-53. PMID: 17998097.
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Miao Y, Shelton T, Quinn TP. Therapeutic efficacy of a 177Lu-labeled DOTA conjugated alpha-melanocyte-stimulating hormone peptide in a murine melanoma-bearing mouse model. Cancer Biother Radiopharm. 2007 Jun; 22(3):333-41. PMID: 17651039.
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Miao Y, Quinn TP. Alpha-melanocyte stimulating hormone peptide-targeted melanoma imaging. Front Biosci. 2007 May 01; 12:4514-24. PMID: 17485393.
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Newton JR, Miao Y, Deutscher SL, Quinn TP. Melanoma imaging with pretargeted bivalent bacteriophage. J Nucl Med. 2007 Mar; 48(3):429-36. PMID: 17332621.
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Miao Y, Benwell K, Quinn TP. 99mTc- and 111In-labeled alpha-melanocyte-stimulating hormone peptides as imaging probes for primary and pulmonary metastatic melanoma detection. J Nucl Med. 2007 Jan; 48(1):73-80. PMID: 17204701.
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Wei L, Butcher C, Miao Y, Gallazzi F, Quinn TP, Welch MJ, Lewis JS. Synthesis and biologic evaluation of 64Cu-labeled rhenium-cyclized alpha-MSH peptide analog using a cross-bridged cyclam chelator. J Nucl Med. 2007 Jan; 48(1):64-72. PMID: 17204700.
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Miao Y, Fisher DR, Quinn TP. Reducing renal uptake of 90Y- and 177Lu-labeled alpha-melanocyte stimulating hormone peptide analogues. Nucl Med Biol. 2006 Aug; 33(6):723-33. PMID: 16934691.
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Miao Y, Hylarides M, Fisher DR, Shelton T, Moore H, Wester DW, Fritzberg AR, Winkelmann CT, Hoffman T, Quinn TP. Melanoma therapy via peptide-targeted {alpha}-radiation. Clin Cancer Res. 2005 Aug 01; 11(15):5616-21. PMID: 16061880.
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Miao Y, Hoffman TJ, Quinn TP. Tumor-targeting properties of 90Y- and 177Lu-labeled alpha-melanocyte stimulating hormone peptide analogues in a murine melanoma model. Nucl Med Biol. 2005 Jul; 32(5):485-93. PMID: 15982579.
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McQuade P, Miao Y, Yoo J, Quinn TP, Welch MJ, Lewis JS. Imaging of melanoma using 64Cu- and 86Y-DOTA-ReCCMSH(Arg11), a cyclized peptide analogue of alpha-MSH. J Med Chem. 2005 Apr 21; 48(8):2985-92. PMID: 15828837.
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Miao Y, Owen NK, Fisher DR, Hoffman TJ, Quinn TP. Therapeutic efficacy of a 188Re-labeled alpha-melanocyte-stimulating hormone peptide analog in murine and human melanoma-bearing mouse models. J Nucl Med. 2005 Jan; 46(1):121-9. PMID: 15632042.
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Miao Y, Whitener D, Feng W, Owen NK, Chen J, Quinn TP. Evaluation of the human melanoma targeting properties of radiolabeled alpha-melanocyte stimulating hormone peptide analogues. Bioconjug Chem. 2003 Nov-Dec; 14(6):1177-84. PMID: 14624632.
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Miao Y, Owen NK, Whitener D, Gallazzi F, Hoffman TJ, Quinn TP. In vivo evaluation of 188Re-labeled alpha-melanocyte stimulating hormone peptide analogs for melanoma therapy. Int J Cancer. 2002 Oct 10; 101(5):480-7. PMID: 12216078.
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Cheng Z, Chen J, Miao Y, Owen NK, Quinn TP, Jurisson SS. Modification of the structure of a metallopeptide: synthesis and biological evaluation of (111)In-labeled DOTA-conjugated rhenium-cyclized alpha-MSH analogues. J Med Chem. 2002 Jul 04; 45(14):3048-56. PMID: 12086490.
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Chen J, Cheng Z, Miao Y, Jurisson SS, Quinn TP. Alpha-melanocyte-stimulating hormone peptide analogs labeled with technetium-99m and indium-111 for malignant melanoma targeting. Cancer. 2002 Feb 15; 94(4 Suppl):1196-201. PMID: 11877745.
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Chen J, Cheng Z, Owen NK, Hoffman TJ, Miao Y, Jurisson SS, Quinn TP. Evaluation of an (111)In-DOTA-rhenium cyclized alpha-MSH analog: a novel cyclic-peptide analog with improved tumor-targeting properties. J Nucl Med. 2001 Dec; 42(12):1847-55. PMID: 11752084.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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Year | Publications |
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2001 | 1 | 2002 | 3 | 2003 | 1 | 2005 | 4 | 2006 | 1 | 2007 | 6 | 2008 | 3 | 2009 | 5 | 2010 | 4 | 2011 | 3 | 2012 | 4 | 2013 | 8 | 2014 | 5 | 2015 | 3 | 2016 | 3 | 2017 | 2 | 2018 | 5 | 2019 | 2 | 2020 | 3 |
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