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Kevin B. Messacar

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS

    Collapse Biography 
    Collapse awards and honors
    2017 - 2018Top Doctor: Pediatric Infectious Diseases, 5280 Magazine
    2018Century Award, Children's Hospital Colorado Medical Staff
    2017Gary Way Award for Outstanding Teaching by a Faculty Member, University of Colorado School of Medicine, Department of Pediatrics
    2015 - 2016Research Scholars Award, Children's Hospital Colorado Research Institute
    2014Astute Clinican Award, Colorado Department of Public Health and Environment
    2013Fellow Teaching Award, University of Colorado School of Medicine, Department of Pediatrics
    2011Resident Teaching Award, University of Colorado School of Medicine
    2011Outstanding Resident of the Year, University of Colorado Hospital Neonatal Care Unit
    2009Outstanding Intern of the Year, University of Colorado Hospital Neonatal Care Unit

    Collapse Overview 
    Collapse overview
    I am a pediatric infectious disease physician and researcher focused on improving diagnostic tests for infectious diseases and better understanding central nervous system infections, such as meningitis, encephalitis, and acute flaccid myelitis.

    Collapse Research 
    Collapse research activities and funding
    K23AI128069     (MESSACAR, KEVIN BRETT)Dec 12, 2016 - Nov 30, 2021
    NIH/NIAID
    Implementation and Effectiveness of a Rapid Cerebrospinal Fluid Diagnostics Program for Children with Suspected Central Nervous System Infection
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Wilson MR, Sample HA, Zorn KC, Arevalo S, Yu G, Neuhaus J, Federman S, Stryke D, Briggs B, Langelier C, Berger A, Douglas V, Josephson SA, Chow FC, Fulton BD, DeRisi JL, Gelfand JM, Naccache SN, Bender J, Dien Bard J, Murkey J, Carlson M, Vespa PM, Vijayan T, Allyn PR, Campeau S, Humphries RM, Klausner JD, Ganzon CD, Memar F, Ocampo NA, Zimmermann LL, Cohen SH, Polage CR, DeBiasi RL, Haller B, Dallas R, Maron G, Hayden R, Messacar K, Dominguez SR, Miller S, Chiu CY. Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis. N Engl J Med. 2019 Jun 13; 380(24):2327-2340. PMID: 31189036.
      View in: PubMed
    2. Abedi GR, Messacar K, Luong W, Nix WA, Rogers S, Queen K, Tong S, Oberste MS, Watt J, Rothrock G, Dominguez S, Gerber SI, Watson JT. Picornavirus etiology of acute infections among hospitalized infants. J Clin Virol. 2019 Apr 25; 116:39-43. PMID: 31100674.
      View in: PubMed
    3. Christy A, Messacar K. Acute Flaccid Myelitis Associated With Enterovirus D68: A Review. J Child Neurol. 2019 Apr 23; 883073819838376. PMID: 31014167.
      View in: PubMed
    4. Miller S, Naccache SN, Samayoa E, Messacar K, Arevalo S, Federman S, Stryke D, Pham E, Fung B, Bolosky WJ, Ingebrigtsen D, Lorizio W, Paff SM, Leake JA, Pesano R, DeBiasi R, Dominguez S, Chiu CY. Laboratory validation of a clinical metagenomic sequencing assay for pathogen detection in cerebrospinal fluid. Genome Res. 2019 May; 29(5):831-842. PMID: 30992304.
      View in: PubMed
    5. Kane MS, Sonne C, Zhu S, Malhotra A, Van Haren K, Messacar K, Glaser CA. Incidence, Risk Factors and Outcomes Among Children With Acute Flaccid Myelitis: A Population-based Cohort Study in a California Health Network Between 2011 and 2016. Pediatr Infect Dis J. 2019 Apr 10. PMID: 30985511.
      View in: PubMed
    6. Messacar K, Tyler KL. Enterovirus D68-Associated Acute Flaccid Myelitis: Rising to the Clinical and Research Challenges. JAMA. 2019 Feb 15. PMID: 30768149.
      View in: PubMed
    7. Messacar K, Pretty K, Reno S, Dominguez SR. Continued biennial circulation of enterovirus D68 in Colorado. J Clin Virol. 2019 Apr; 113:24-26. PMID: 30825833.
      View in: PubMed
    8. Rao S, Martin J, Ahearn MA, Osborne C, Moss A, Dempsey A, Dominguez SR, Weinberg A, Messacar KB. Neurologic Manifestations of Influenza A(H3N2) Infection in Children During the 2016-2017 Season. J Pediatric Infect Dis Soc. 2018 Dec 27. PMID: 30590598.
      View in: PubMed
    9. Dubey D, Pittock SJ, Krecke KN, Morris PP, Sechi E, Zalewski NL, Weinshenker BG, Shosha E, Lucchinetti CF, Fryer JP, Lopez-Chiriboga AS, Chen JC, Jitprapaikulsan J, McKeon A, Gadoth A, Keegan BM, Tillema JM, Naddaf E, Patterson MC, Messacar K, Tyler KL, Flanagan EP. Clinical, Radiologic, and Prognostic Features of Myelitis Associated With Myelin Oligodendrocyte Glycoprotein Autoantibody. JAMA Neurol. 2018 Dec 21. PMID: 30575890.
      View in: PubMed
    10. Saporta-Keating SR, Simões EAF, Yu G, Federman S, Mirsky D, Dominguez SR, Chiu CY, Messacar K. A Child With Intermittent Headaches and Eosinophilic Meningitis. J Pediatric Infect Dis Soc. 2018 Dec 03; 7(4):355-357. PMID: 29438532.
      View in: PubMed
    11. Elrick MJ, Gordon-Lipkin E, Crawford TO, Van Haren K, Messacar K, Thornton N, Dee E, Voskertchian A, Nance JR, Muñoz LS, Gorman MP, Benson LA, Thomas DL, Pardo CA, Milstone AM, Duggal P. Clinical Subpopulations in a Sample of North American Children Diagnosed With Acute Flaccid Myelitis, 2012-2016. JAMA Pediatr. 2018 Nov 30. PMID: 30500056.
      View in: PubMed
    12. Hopkins SE, Elrick MJ, Messacar K. Acute Flaccid Myelitis-Keys to Diagnosis, Questions About Treatment, and Future Directions. JAMA Pediatr. 2018 Nov 30. PMID: 30500054.
      View in: PubMed
    13. Messacar K, Robinson CC, Dominguez SR. Letter to the editor: economic analysis lacks external validity to support universal syndromic testing for suspected meningitis/encephalitis. Future Microbiol. 2018 11; 13:1553-1554. PMID: 30421966.
      View in: PubMed
    14. Messacar K, Sillau S, Hopkins SE, Otten C, Wilson-Murphy M, Wong B, Santoro JD, Treister A, Bains HK, Torres A, Zabrocki L, Glanternik JR, Hurst AL, Martin JA, Schreiner T, Makhani N, DeBiasi RL, Kruer MC, Tremoulet AH, Van Haren K, Desai J, Benson LA, Gorman MP, Abzug MJ, Tyler KL, Dominguez SR. Safety, tolerability, and efficacy of fluoxetine as an antiviral for acute flaccid myelitis. Neurology. 2019 Apr 30; 92(18):e2118-e2126. PMID: 30413631.
      View in: PubMed
    15. Messacar K, Dominguez SR. Blood PCR testing for enteroviruses in young children. Lancet Infect Dis. 2018 Dec; 18(12):1299-1301. PMID: 30389483.
      View in: PubMed
    16. Searns J, Cataldi JR, McCormack K, Simões E, Messacar K, Dominguez SR. A 4-Year-Old Boy With an Unusual Bacterial Meningitis Infection. J Pediatric Infect Dis Soc. 2018 Oct 09. PMID: 30299497.
      View in: PubMed
    17. Messacar K, Burakoff A, Nix WA, Rogers S, Oberste MS, Gerber SI, Spence-Davizon E, Herlihy R, Dominguez SR. Notes from the Field: Enterovirus A71 Neurologic Disease in Children - Colorado, 2018. MMWR Morb Mortal Wkly Rep. 2018 Sep 14; 67(36):1017-1018. PMID: 30212441.
      View in: PubMed
    18. Messacar K, Hamilton SL, Prinzi AM, Mitchell JC, Beil ED, Dowell EB, Dominguez SR. Rapid identification of nonblood sterile site broth cultures using the FilmArray blood culture identification panel. Diagn Microbiol Infect Dis. 2019 Jan; 93(1):22-23. PMID: 30213466.
      View in: PubMed
    19. Messacar K. Narrow-spectrum, compared with broad-spectrum, antibiotics equally effective with less adverse events. J Pediatr. 2018 05; 196:324-327. PMID: 29703366.
      View in: PubMed
    20. Messacar K, Asturias EJ, Hixon AM, Van Leer-Buter C, Niesters HGM, Tyler KL, Abzug MJ, Dominguez SR. Enterovirus D68 and acute flaccid myelitis-evaluating the evidence for causality. Lancet Infect Dis. 2018 08; 18(8):e239-e247. PMID: 29482893.
      View in: PubMed
    21. Messacar K, Fischer M, Dominguez SR, Tyler KL, Abzug MJ. Encephalitis in US Children. Infect Dis Clin North Am. 2018 03; 32(1):145-162. PMID: 29224854.
      View in: PubMed
    22. Messacar K, Parker SK, Todd JK, Dominguez SR. Reply to "Integrated Stewardship Model Comprising Antimicrobial, Infection Prevention, and Diagnostic Stewardship (AID Stewardship)". J Clin Microbiol. 2017 11; 55(11):3308. PMID: 29066568.
      View in: PubMed
    23. Messacar K, Abzug MJ, Dominguez SR. The changing epidemiology of acute flaccid paralysis warrants a paradigm shift in surveillance. J Med Virol. 2018 01; 90(1):1-2. PMID: 29023852.
      View in: PubMed
    24. Messacar K, Hurst AL, Child J, Campbell K, Palmer C, Hamilton S, Dowell E, Robinson CC, Parker SK, Dominguez SR. Clinical Impact and Provider Acceptability of Real-Time Antimicrobial Stewardship Decision Support for Rapid Diagnostics in Children With Positive Blood Culture Results. J Pediatric Infect Dis Soc. 2017 Sep 01; 6(3):267-274. PMID: 27543412.
      View in: PubMed
    25. Martin JA, Messacar K, Yang ML, Maloney JA, Lindwall J, Carry T, Kenyon P, Sillau SH, Oleszek J, Tyler KL, Dominguez SR, Schreiner TL. Outcomes of Colorado children with acute flaccid myelitis at 1 year. Neurology. 2017 Jul 11; 89(2):129-137. PMID: 28615421.
      View in: PubMed
    26. Messacar K, Campbell K, Pearce K, Pyle L, Hurst AL, Child J, Parker SK. A Handshake From Antimicrobial Stewardship Opens Doors for Infectious Disease Consultations. Clin Infect Dis. 2017 May 15; 64(10):1449-1452. PMID: 28186533.
      View in: PubMed
    27. Messacar K, Robinson CC, Pretty K, Yuan J, Dominguez SR. Surveillance for enterovirus D68 in colorado children reveals continued circulation. J Clin Virol. 2017 07; 92:39-41. PMID: 28521212.
      View in: PubMed
    28. Alvarez E, Seppa M, Rivas S, Fuentes L, Valverde P, Antillón-Klussmann F, Castellanos M, Sweet-Cordero EA, Messacar K, Kurap J, Bustamante M, Howard SC, Efron B, Luna-Fineman S. Improvement in treatment abandonment in pediatric patients with cancer in Guatemala. Pediatr Blood Cancer. 2017 Oct; 64(10). PMID: 28423236.
      View in: PubMed
    29. Messacar K, Parker SK, Todd JK, Dominguez SR. Implementation of Rapid Molecular Infectious Disease Diagnostics: the Role of Diagnostic and Antimicrobial Stewardship. J Clin Microbiol. 2017 03; 55(3):715-723. PMID: 28031432.
      View in: PubMed
    30. Rao S, Messacar K, Torok MR, Rick AM, Holzberg J, Montano A, Bagdure D, Curtis DJ, Oberste MS, Nix WA, de Masellis G, Robinson CC, Dominguez SR. Enterovirus D68 in Critically Ill Children: A Comparison With Pandemic H1N1 Influenza. Pediatr Crit Care Med. 2016 11; 17(11):1023-1031. PMID: 27505715.
      View in: PubMed
    31. Phan TG, Messacar K, Dominguez SR, da Costa AC, Deng X, Delwart E. A new densovirus in cerebrospinal fluid from a case of anti-NMDA-receptor encephalitis. Arch Virol. 2016 Nov; 161(11):3231-5. PMID: 27522586.
      View in: PubMed
    32. Messacar K, Schreiner TL, Van Haren K, Yang M, Glaser CA, Tyler KL, Dominguez SR. Acute flaccid myelitis: A clinical review of US cases 2012-2015. Ann Neurol. 2016 09; 80(3):326-38. PMID: 27422805.
      View in: PubMed
    33. Aliabadi N, Messacar K, Pastula DM, Robinson CC, Leshem E, Sejvar JJ, Nix WA, Oberste MS, Feikin DR, Dominguez SR. Enterovirus D68 Infection in Children with Acute Flaccid Myelitis, Colorado, USA, 2014. Emerg Infect Dis. 2016 08; 22(8):1387-94. PMID: 27434186.
      View in: PubMed
    34. White A, Olson D, Messacar K. A state-wide assessment of the association between epidural analgesia, maternal fever and neonatal antibiotics in Colorado, 2007-2012. Arch Dis Child Fetal Neonatal Ed. 2017 Mar; 102(2):F120-F125. PMID: 27343198.
      View in: PubMed
    35. Messacar K, Breazeale G, Robinson CC, Dominguez SR. Potential clinical impact of the film array meningitis encephalitis panel in children with suspected central nervous system infections. Diagn Microbiol Infect Dis. 2016 Sep; 86(1):118-20. PMID: 27342782.
      View in: PubMed
    36. Messacar K, Abzug MJ, Dominguez SR. The Emergence of Enterovirus-D68. Microbiol Spectr. 2016 06; 4(3). PMID: 27337448.
      View in: PubMed
    37. Bagdure D, Custer JW, Rao S, Messacar K, Dominguez S, Beam BW, Bhutta A. Hospitalized Children With Encephalitis in the United States: A Pediatric Health Information System Database Study. Pediatr Neurol. 2016 08; 61:58-62. PMID: 27353693.
      View in: PubMed
    38. Messacar K, Hawkins SM, Baker J, Pearce K, Tong S, Dominguez SR, Parker S. Resource Burden During the 2014 Enterovirus D68 Respiratory Disease Outbreak at Children's Hospital Colorado: An Unexpected Strain. JAMA Pediatr. 2016 Mar; 170(3):294-7. PMID: 26783716.
      View in: PubMed
    39. Greninger AL, Messacar K, Dunnebacke T, Naccache SN, Federman S, Bouquet J, Mirsky D, Nomura Y, Yagi S, Glaser C, Vollmer M, Press CA, Kleinschmidt-DeMasters BK, Dominguez SR, Chiu CY. Erratum to: Clinical metagenomic identification of Balamuthia mandrillaris encephalitis and assembly of the draft genome: the continuing case for reference genome sequencing. Genome Med. 2016 Jan 11; 8(1):1. PMID: 26750923.
      View in: PubMed
    40. Good RJ, Messacar K, Stence NV, Press CA, Carpenter TC. Abnormal Neuroimaging in a Case of Infant Botulism. Front Pediatr. 2015; 3:108. PMID: 26697417.
      View in: PubMed
    41. Greninger AL, Messacar K, Dunnebacke T, Naccache SN, Federman S, Bouquet J, Mirsky D, Nomura Y, Yagi S, Glaser C, Vollmer M, Press CA, Kleinschmidt-DeMasters BK, Klenschmidt-DeMasters BK, Dominguez SR, Chiu CY. Clinical metagenomic identification of Balamuthia mandrillaris encephalitis and assembly of the draft genome: the continuing case for reference genome sequencing. Genome Med. 2015 Dec 01; 7:113. PMID: 26620704.
      View in: PubMed
    42. Messacar K, Abzug MJ, Dominguez SR. 2014 outbreak of enterovirus D68 in North America. J Med Virol. 2016 May; 88(5):739-45. PMID: 26489019.
      View in: PubMed
    43. Greninger AL, Naccache SN, Messacar K, Clayton A, Yu G, Somasekar S, Federman S, Stryke D, Anderson C, Yagi S, Messenger S, Wadford D, Xia D, Watt JP, Van Haren K, Dominguez SR, Glaser C, Aldrovandi G, Chiu CY. A novel outbreak enterovirus D68 strain associated with acute flaccid myelitis cases in the USA (2012-14): a retrospective cohort study. Lancet Infect Dis. 2015 Jun; 15(6):671-82. PMID: 25837569.
      View in: PubMed
    44. Messacar K, Breazeale G, Wei Q, Robinson CC, Dominguez SR. Epidemiology and clinical characteristics of infants with human parechovirus or human herpes virus-6 detected in cerebrospinal fluid tested for enterovirus or herpes simplex virus. J Med Virol. 2015 May; 87(5):829-35. PMID: 25650069.
      View in: PubMed
    45. Messacar K, Schreiner TL, Maloney JA, Wallace A, Ludke J, Oberste MS, Nix WA, Robinson CC, Glodé MP, Abzug MJ, Dominguez SR. A cluster of acute flaccid paralysis and cranial nerve dysfunction temporally associated with an outbreak of enterovirus D68 in children in Colorado, USA. Lancet. 2015 Apr 25; 385(9978):1662-71. PMID: 25638662.
      View in: PubMed
    46. Maloney JA, Mirsky DM, Messacar K, Dominguez SR, Schreiner T, Stence NV. MRI findings in children with acute flaccid paralysis and cranial nerve dysfunction occurring during the 2014 enterovirus D68 outbreak. AJNR Am J Neuroradiol. 2015 Feb; 36(2):245-50. PMID: 25414005.
      View in: PubMed
    47. Pastula DM, Aliabadi N, Haynes AK, Messacar K, Schreiner T, Maloney J, Dominguez SR, Davizon ES, Leshem E, Fischer M, Nix WA, Oberste MS, Seward J, Feikin D, Miller L. Acute neurologic illness of unknown etiology in children - Colorado, August-September 2014. MMWR Morb Mortal Wkly Rep. 2014 Oct 10; 63(40):901-2. PMID: 25299607.
      View in: PubMed
    48. Gaensbauer JT, Lindsey NP, Messacar K, Staples JE, Fischer M. Neuroinvasive arboviral disease in the United States: 2003 to 2012. Pediatrics. 2014 Sep; 134(3):e642-50. PMID: 25113294.
      View in: PubMed
    49. LaGreca J, Hotchkiss M, Carry P, Messacar K, Nyquist AC, Erickson M, Garg S. Bacteriology and Risk Factors for Development of Late (Greater Than One Year) Deep Infection Following Spinal Fusion With Instrumentation. Spine Deform. 2014 May; 2(3):186-190. PMID: 27927416.
      View in: PubMed
    50. Messacar K, Dunn J, Dominguez,SR, Khan T, McFarland EJ. Diffuse Nodular Lung Infiltrates in a Three-Year-Old Boy with Recurrent Sinopulmonary Infections and Parotitis. Journal of the Pediatric Infectious Disease Society. 2014.
    51. Messacar K, Dunn J, Khan TZ, Etcheverry A, McFarland EJ, Dominguez SR. Diffuse Nodular Lung Infiltrates in a Well Appearing Three-Year-Old Boy With Recurrent Sinopulmonary Infections and Parotitis. J Pediatric Infect Dis Soc. 2015 Mar; 4(1):74-7. PMID: 26407362.
      View in: PubMed
    52. Messacar K, Cree-Green M, Lovell M, Anderson MS, Dominguez SR. Severe Neuroinvasive West Nile Virus Infection in a Child with Undiagnosed Addison's Disease. IDCases. 2014; 1(3):29-31. PMID: 25133095.
      View in: PubMed
    53. Bacteriology and Risk Factors for Development of Late (Greater Than One Year) Deep Infection Following Spinal Fusion Instrumentation. One Year) Deep Infection Following Spinal Fusion With Instrumentation. Spine Deformity. 2013; 3(2):186-90.
    54. Messacar K, Robinson CC, Bagdure D, Curtis DJ, Glodé MP, Dominguez SR. Rhino/enteroviruses in hospitalized children: a comparison to influenza viruses. J Clin Virol. 2013 Jan; 56(1):41-5. PMID: 23078869.
      View in: PubMed
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