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James York E Miller

TitleProfessor-Clinical
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/399-8020

    Collapse Biography 
    Collapse education and training
    Harvard College, Cambridge, MAAB06/1972Biochemical Sciences
    Duke University SOM, Durham, NCMD06/1976Medicine
    Barnes Hospital, Washington University, St. Louis, MO07/1978Internal Medicine
    University of Colorado, Denver, CO07/1979Internal Medicine
    University of Colorado, Denver, CO07/1982Pulmonary/Critical Care Medicine
    Eleanor Roosevelt Institute for Cancer Research, Denver, CO07/1982Genetics

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    V Foundation Translational Research Award     (Miller, York)Oct 1, 2017 - Oct 31, 2021
    V Foundation
    Precision Chemoprevention of Lung Cancer
    Role Description: Develop a predictive biomarker for iloprost chemoprevention of lung cancer.
    Role: PI
    R01CA219893     (GHOSH, MOUMITA ;MILLER, YORK E)Sep 1, 2017 - Aug 31, 2023
    NIH
    (PQ1) Progenitor cell malfunction, mutations and changes in microenvironment: A dynamic risk spectrum for cancer evolution
    Role: Co-Investigator
    HHSN2612012000351-0-26100004-1     (Miller, York)Aug 26, 2014 - Dec 31, 2020
    NCI
    A Phase I Trial of Inhaled Iloprost for the Prevention of Lung Cancer in Former Smokers
    Role Description: Determine toxicity and compliance for inhaled iloprost for chemoprevention of lung cancer in former smokers.
    Role: PI

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Warsavage T, Xing F, Bar?n AE, Feser WJ, Hirsch E, Miller YE, Malkoski S, Wolf HJ, Wilson DO, Ghosh D. Quantifying the incremental value of deep learning: Application to lung nodule detection. PLoS One. 2020; 15(4):e0231468. PMID: 32287288.
      View in: PubMed
    2. Keith RL, Blatchford PJ, Merrick DT, Bunn PA, Bagwell B, Dwyer-Nield LD, Jackson MK, Geraci MW, Miller YE. A Randomized Phase II Trial of Pioglitazone for Lung Cancer Chemoprevention in High-Risk Current and Former Smokers. Cancer Prev Res (Phila). 2019 10; 12(10):721-730. PMID: 31308004.
      View in: PubMed
    3. Merrick DT, Edwards MG, Franklin WA, Sugita M, Keith RL, Miller YE, Friedman MB, Dwyer-Nield LD, Tennis MA, O'Keefe MC, Donald EJ, Malloy JM, van Bokhoven A, Wilson S, Koch PJ, O'Shea C, Coldren C, Orlicky DJ, Lu X, Baron AE, Hickey G, Kennedy TC, Powell R, Heasley L, Bunn PA, Geraci M, Nemenoff RA. Altered Cell-Cycle Control, Inflammation, and Adhesion in High-Risk Persistent Bronchial Dysplasia. Cancer Res. 2018 09 01; 78(17):4971-4983. PMID: 29997230.
      View in: PubMed
    4. Ghosh M, Miller YE, Nakachi I, Kwon JB, Bar?n AE, Brantley AE, Merrick DT, Franklin WA, Keith RL, Vandivier RW. Exhaustion of Airway Basal Progenitor Cells in Early and Established Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2018 04 01; 197(7):885-896. PMID: 29211494.
      View in: PubMed
    5. Merrick DT, Gao D, Miller YE, Keith RL, Baron AE, Feser W, Kennedy TC, Blatchford PJ, Braudrick S, Hirsch FR, Heasley L, Bunn PA, Franklin WA. Persistence of Bronchial Dysplasia Is Associated with Development of Invasive Squamous Cell Carcinoma. Cancer Prev Res (Phila). 2016 Jan; 9(1):96-104. PMID: 26542061.
      View in: PubMed
    6. Krefft SD, Rose CS, Nawaz S, Miller YE. Deployment-Related Lung Disorders. Fed Pract. 2015 Sep; 32(Suppl 10):24S-31S. PMID: 30766097.
      View in: PubMed
    7. Vachani A, Pass HI, Rom WN, Midthun DE, Edell ES, Laviolette M, Li XJ, Fong PY, Hunsucker SW, Hayward C, Mazzone PJ, Madtes DK, Miller YE, Walker MG, Shi J, Kearney P, Fang KC, Massion PP. Validation of a multiprotein plasma classifier to identify benign lung nodules. J Thorac Oncol. 2015 Apr; 10(4):629-37. PMID: 25590604.
      View in: PubMed
    8. Mehan MR, Williams SA, Siegfried JM, Bigbee WL, Weissfeld JL, Wilson DO, Pass HI, Rom WN, Muley T, Meister M, Franklin W, Miller YE, Brody EN, Ostroff RM. Validation of a blood protein signature for non-small cell lung cancer. Clin Proteomics. 2014; 11(1):32. PMID: 25114662.
      View in: PubMed
    9. Nakachi I, Rice JL, Coldren CD, Edwards MG, Stearman RS, Glidewell SC, Varella-Garcia M, Franklin WA, Keith RL, Lewis MT, Gao B, Merrick DT, Miller YE, Geraci MW. Application of SNP microarrays to the genome-wide analysis of chromosomal instability in premalignant airway lesions. Cancer Prev Res (Phila). 2014 Feb; 7(2):255-65. PMID: 24346345.
      View in: PubMed
    10. Keith RL, Miller YE. Lung cancer chemoprevention: current status and future prospects. Nat Rev Clin Oncol. 2013 Jun; 10(6):334-43. PMID: 23689750.
      View in: PubMed
    11. Mascaux C, Feser WJ, Lewis MT, Bar?n AE, Coldren CD, Merrick DT, Kennedy TC, Eckelberger JI, Rozeboom LM, Franklin WA, Minna JD, Bunn PA, Miller YE, Keith RL, Hirsch FR. Endobronchial miRNAs as biomarkers in lung cancer chemoprevention. Cancer Prev Res (Phila). 2013 Feb; 6(2):100-8. PMID: 23268837.
      View in: PubMed
    12. Peled N, Hakim M, Bunn PA, Miller YE, Kennedy TC, Mattei J, Mitchell JD, Hirsch FR, Haick H. Non-invasive breath analysis of pulmonary nodules. J Thorac Oncol. 2012 Oct; 7(10):1528-33. PMID: 22929969.
      View in: PubMed
    13. Karoor V, Le M, Merrick D, Fagan KA, Dempsey EC, Miller YE. Alveolar hypoxia promotes murine lung tumor growth through a VEGFR-2/EGFR-dependent mechanism. Cancer Prev Res (Phila). 2012 Aug; 5(8):1061-71. PMID: 22700853.
      View in: PubMed
    14. Egloff AM, Gaither Davis A, Shuai Y, Land S, Pilewski JM, Luketich JD, Landreneau R, Miller YE, Grandis JR, Siegfried JM. Gastrin-releasing peptide receptor expression in non-cancerous bronchial epithelia is associated with lung cancer: a case-control study. Respir Res. 2012 Feb 01; 13:9. PMID: 22296774.
      View in: PubMed
    15. Coldren CD, Miller YE. Progressive endobronchial premalignancy: marked by original CIN. Am J Respir Crit Care Med. 2011 Oct 15; 184(8):869-70. PMID: 22003147.
      View in: PubMed
    16. Keith RL, Blatchford PJ, Kittelson J, Minna JD, Kelly K, Massion PP, Franklin WA, Mao J, Wilson DO, Merrick DT, Hirsch FR, Kennedy TC, Bunn PA, Geraci MW, Miller YE. Oral iloprost improves endobronchial dysplasia in former smokers. Cancer Prev Res (Phila). 2011 Jun; 4(6):793-802. PMID: 21636546.
      View in: PubMed
    17. Rafnar T, Sulem P, Besenbacher S, Gudbjartsson DF, Zanon C, Gudmundsson J, Stacey SN, Kostic JP, Thorgeirsson TE, Thorleifsson G, Bjarnason H, Skuladottir H, Gudbjartsson T, Isaksson HJ, Isla D, Murillo L, Garc?a-Prats MD, Panadero A, Aben KK, Vermeulen SH, van der Heijden HF, Feser WJ, Miller YE, Bunn PA, Kong A, Wolf HJ, Franklin WA, Mayordomo JI, Kiemeney LA, Jonsson S, Thorsteinsdottir U, Stefansson K. Genome-wide significant association between a sequence variant at 15q15.2 and lung cancer risk. Cancer Res. 2011 Feb 15; 71(4):1356-61. PMID: 21303977.
      View in: PubMed
    18. Ostroff RM, Bigbee WL, Franklin W, Gold L, Mehan M, Miller YE, Pass HI, Rom WN, Siegfried JM, Stewart A, Walker JJ, Weissfeld JL, Williams S, Zichi D, Brody EN. Unlocking biomarker discovery: large scale application of aptamer proteomic technology for early detection of lung cancer. PLoS One. 2010 Dec 07; 5(12):e15003. PMID: 21170350.
      View in: PubMed
    19. Karoor V, Le M, Merrick D, Dempsey EC, Miller YE. Vascular endothelial growth factor receptor 2-targeted chemoprevention of murine lung tumors. Cancer Prev Res (Phila). 2010 Sep; 3(9):1141-7. PMID: 20647338.
      View in: PubMed
    20. Varella-Garcia M, Schulte AP, Wolf HJ, Feser WJ, Zeng C, Braudrick S, Yin X, Hirsch FR, Kennedy TC, Keith RL, Bar?n AE, Belinsky SA, Miller YE, Byers T, Franklin WA. The detection of chromosomal aneusomy by fluorescence in situ hybridization in sputum predicts lung cancer incidence. Cancer Prev Res (Phila). 2010 Apr; 3(4):447-53. PMID: 20332298.
      View in: PubMed
    21. Kim WY, Jin Q, Oh SH, Kim ES, Yang YJ, Lee DH, Feng L, Behrens C, Prudkin L, Miller YE, Lee JJ, Lippman SM, Hong WK, Wistuba II, Lee HY. Elevated epithelial insulin-like growth factor expression is a risk factor for lung cancer development. Cancer Res. 2009 Sep 15; 69(18):7439-48. PMID: 19738076.
      View in: PubMed
    22. Massion PP, Zou Y, Uner H, Kiatsimkul P, Wolf HJ, Baron AE, Byers T, Jonsson S, Lam S, Hirsch FR, Miller YE, Franklin WA, Varella-Garcia M. Recurrent genomic gains in preinvasive lesions as a biomarker of risk for lung cancer. PLoS One. 2009 Jun 09; 4(6):e5611. PMID: 19547694.
      View in: PubMed
    23. Kelly K, Kittelson J, Franklin WA, Kennedy TC, Klein CE, Keith RL, Dempsey EC, Lewis M, Jackson MK, Hirsch FR, Bunn PA, Miller YE. A randomized phase II chemoprevention trial of 13-CIS retinoic acid with or without alpha tocopherol or observation in subjects at high risk for lung cancer. Cancer Prev Res (Phila). 2009 May; 2(5):440-9. PMID: 19401528.
      View in: PubMed
    24. Edell E, Lam S, Pass H, Miller YE, Sutedja T, Kennedy T, Loewen G, Keith RL, Gazdar A. Detection and localization of intraepithelial neoplasia and invasive carcinoma using fluorescence-reflectance bronchoscopy: an international, multicenter clinical trial. J Thorac Oncol. 2009 Jan; 4(1):49-54. PMID: 19096306.
      View in: PubMed
    25. Miller YE. Minimizing unintended consequences of detecting lung nodules by computed tomography. Am J Respir Crit Care Med. 2008 Nov 01; 178(9):891-2. PMID: 18945870.
      View in: PubMed
    26. Minowada G, Miller YE. Overexpression of Sprouty 2 in mouse lung epithelium inhibits urethane-induced tumorigenesis. Am J Respir Cell Mol Biol. 2009 Jan; 40(1):31-7. PMID: 18635814.
      View in: PubMed
    27. Byers T, Wolf HJ, Franklin WA, Braudrick S, Merrick DT, Shroyer KR, Hirsch FR, Zeng C, Bar?n AE, Bunn PA, Miller YE, Kennedy TC. Sputum cytologic atypia predicts incident lung cancer: defining latency and histologic specificity. Cancer Epidemiol Biomarkers Prev. 2008 Jan; 17(1):158-62. PMID: 18199720.
      View in: PubMed
    28. Jonsson S, Varella-Garcia M, Miller YE, Wolf HJ, Byers T, Braudrick S, Kiatsimkul P, Lewis M, Kennedy TC, Keith RL, Bjornsson J, McWilliams A, Lam S, Hirsch FR, Franklin WA. Chromosomal aneusomy in bronchial high-grade lesions is associated with invasive lung cancer. Am J Respir Crit Care Med. 2008 Feb 01; 177(3):342-7. PMID: 17989344.
      View in: PubMed
    29. Miller YE, Blatchford P, Hyun DS, Keith RL, Kennedy TC, Wolf H, Byers T, Bunn PA, Lewis MT, Franklin WA, Hirsch FR, Kittelson J. Bronchial epithelial Ki-67 index is related to histology, smoking, and gender, but not lung cancer or chronic obstructive pulmonary disease. Cancer Epidemiol Biomarkers Prev. 2007 Nov; 16(11):2425-31. PMID: 18006932.
      View in: PubMed
    30. Varella-Garcia M, Chen L, Powell RL, Hirsch FR, Kennedy TC, Keith R, Miller YE, Mitchell JD, Franklin WA. Spectral karyotyping detects chromosome damage in bronchial cells of smokers and patients with cancer. Am J Respir Crit Care Med. 2007 Sep 01; 176(5):505-12. PMID: 17600274.
      View in: PubMed
    31. Merrick DT, Haney J, Petrunich S, Sugita M, Miller YE, Keith RL, Kennedy TC, Franklin WA. Overexpression of vascular endothelial growth factor and its receptors in bronchial dypslasia demonstrated by quantitative RT-PCR analysis. Lung Cancer. 2005 Apr; 48(1):31-45. PMID: 15777969.
      View in: PubMed
    32. Keith RL, Miller YE, Hudish TM, Girod CE, Sotto-Santiago S, Franklin WA, Nemenoff RA, March TH, Nana-Sinkam SP, Geraci MW. Pulmonary prostacyclin synthase overexpression chemoprevents tobacco smoke lung carcinogenesis in mice. Cancer Res. 2004 Aug 15; 64(16):5897-904. PMID: 15313935.
      View in: PubMed
    33. Fessler MB, Cool CD, Miller YE, Schwarz MI, Brown KK. Idiopathic diffuse hyperplasia of pulmonary neuroendocrine cells in a patient with acromegaly. Respirology. 2004 Jun; 9(2):274-7. PMID: 15182282.
      View in: PubMed
    34. Varella-Garcia M, Kittelson J, Schulte AP, Vu KO, Wolf HJ, Zeng C, Hirsch FR, Byers T, Kennedy T, Miller YE, Keith RL, Franklin WA. Multi-target interphase fluorescence in situ hybridization assay increases sensitivity of sputum cytology as a predictor of lung cancer. Cancer Detect Prev. 2004; 28(4):244-51. PMID: 15350627.
      View in: PubMed
    35. Prindiville SA, Byers T, Hirsch FR, Franklin WA, Miller YE, Vu KO, Wolf HJ, Bar?n AE, Shroyer KR, Zeng C, Kennedy TC, Bunn PA. Sputum cytological atypia as a predictor of incident lung cancer in a cohort of heavy smokers with airflow obstruction. Cancer Epidemiol Biomarkers Prev. 2003 Oct; 12(10):987-93. PMID: 14578133.
      View in: PubMed
    36. Garg K, Keith RL, Byers T, Kelly K, Kerzner AL, Lynch DA, Miller YE. Randomized controlled trial with low-dose spiral CT for lung cancer screening: feasibility study and preliminary results. Radiology. 2002 Nov; 225(2):506-10. PMID: 12409588.
      View in: PubMed
    37. Keith RL, Miller YE, Hoshikawa Y, Moore MD, Gesell TL, Gao B, Malkinson AM, Golpon HA, Nemenoff RA, Geraci MW. Manipulation of pulmonary prostacyclin synthase expression prevents murine lung cancer. Cancer Res. 2002 Feb 01; 62(3):734-40. PMID: 11830527.
      View in: PubMed
    38. Hirsch FR, Prindiville SA, Miller YE, Franklin WA, Dempsey EC, Murphy JR, Bunn PA, Kennedy TC. Fluorescence versus white-light bronchoscopy for detection of preneoplastic lesions: a randomized study. J Natl Cancer Inst. 2001 Sep 19; 93(18):1385-91. PMID: 11562389.
      View in: PubMed
    39. Keith RL, Miller YE, Gemmill RM, Drabkin HA, Dempsey EC, Kennedy TC, Prindiville S, Franklin WA. Angiogenic squamous dysplasia in bronchi of individuals at high risk for lung cancer. Clin Cancer Res. 2000 May; 6(5):1616-25. PMID: 10815878.
      View in: PubMed
    40. Girod CE, Shin DH, Geraci MW, Warren HB, Dobbs LG, Gao B, Rainer JS, Bauer AK, Ikegami M, Shannon JM, Miller YE. Surfactant protein C promoter-driven expression of T1-alpha induces lung inflammation. Chest. 1999 Jul; 116(1 Suppl):61S. PMID: 10424594.
      View in: PubMed
    41. Scher H, Miller YE, Aguayo SM, Johnson KJ, Miller JE, McCray PB. Urinary bombesin-like peptide levels in infants and children with bronchopulmonary dysplasia and cystic fibrosis. Pediatr Pulmonol. 1998 Nov; 26(5):326-31. PMID: 9859901.
      View in: PubMed
    42. Bunn PA, Helfrich BA, Brenner DG, Chan DC, Dykes DJ, Cohen AJ, Miller YE. Effects of recombinant neutral endopeptidase (EC 3.4.24.11) on the growth of lung cancer cell lines in vitro and in vivo. Clin Cancer Res. 1998 Nov; 4(11):2849-58. PMID: 9829752.
      View in: PubMed
    43. Cohen AJ, King TE, Gilman LB, Magill-Solc C, Miller YE. High expression of neutral endopeptidase in idiopathic diffuse hyperplasia of pulmonary neuroendocrine cells. Am J Respir Crit Care Med. 1998 Nov; 158(5 Pt 1):1593-9. PMID: 9817713.
      View in: PubMed
    44. Cook RM, Franklin WA, Moore MD, Johnson BE, Miller YE. Mutational inactivation of aminoacylase-I in a small cell lung cancer cell line. Genes Chromosomes Cancer. 1998 Apr; 21(4):320-5. PMID: 9559343.
      View in: PubMed
    45. Lam S, Kennedy T, Unger M, Miller YE, Gelmont D, Rusch V, Gipe B, Howard D, LeRiche JC, Coldman A, Gazdar AF. Localization of bronchial intraepithelial neoplastic lesions by fluorescence bronchoscopy. Chest. 1998 Mar; 113(3):696-702. PMID: 9515845.
      View in: PubMed
    46. Gallione CJ, Klaus DJ, Yeh EY, Stenzel TT, Xue Y, Anthony KB, McAllister KA, Baldwin MA, Berg JN, Lux A, Smith JD, Vary CP, Craigen WJ, Westermann CJ, Warner ML, Miller YE, Jackson CE, Guttmacher AE, Marchuk DA. Mutation and expression analysis of the endoglin gene in hereditary hemorrhagic telangiectasia reveals null alleles. Hum Mutat. 1998; 11(4):286-94. PMID: 9554745.
      View in: PubMed
    47. Franklin WA, Gazdar AF, Haney J, Wistuba II, La Rosa FG, Kennedy T, Ritchey DM, Miller YE. Widely dispersed p53 mutation in respiratory epithelium. A novel mechanism for field carcinogenesis. J Clin Invest. 1997 Oct 15; 100(8):2133-7. PMID: 9329980.
      View in: PubMed
    48. Girod CE, Shin DH, Hershenson MB, Solway J, Redlich CA, Gilman LB, Miller YE. 2A3 and 3F9. Novel lung epithelial antigens with early upregulation in hyperoxic and radiation lung injury models. Chest. 1996 Mar; 109(3 Suppl):33S. PMID: 8598142.
      View in: PubMed
    49. Cohen AJ, Gilman LB, Moore M, Franklin WA, Miller YE. Inactivation of neutral endopeptidase in lung cancer. Chest. 1996 Mar; 109(3 Suppl):12S-13S. PMID: 8598132.
      View in: PubMed
    50. Cohen AJ, Bunn PA, Franklin W, Magill-Solc C, Hartmann C, Helfrich B, Gilman L, Folkvord J, Helm K, Miller YE. Neutral endopeptidase: variable expression in human lung, inactivation in lung cancer, and modulation of peptide-induced calcium flux. Cancer Res. 1996 Feb 15; 56(4):831-9. PMID: 8631021.
      View in: PubMed
    51. Geraci MW, Miller YE, Escobedo-Morse A, Kane MA. Novel bombesin-like peptide binding proteins from lung. Am J Respir Cell Mol Biol. 1994 Mar; 10(3):331-8. PMID: 8117451.
      View in: PubMed
    52. Lindberg FP, Lublin DM, Telen MJ, Veile RA, Miller YE, Donis-Keller H, Brown EJ. Rh-related antigen CD47 is the signal-transducer integrin-associated protein. J Biol Chem. 1994 Jan 21; 269(3):1567-70. PMID: 8294396.
      View in: PubMed
    53. Cook RM, Burke BJ, Buchhagen DL, Minna JD, Miller YE. Human aminoacylase-1. Cloning, sequence, and expression analysis of a chromosome 3p21 gene inactivated in small cell lung cancer. J Biol Chem. 1993 Aug 15; 268(23):17010-7. PMID: 8394326.
      View in: PubMed
    54. Aguayo SM, Miller YE, Waldron JA, Bogin RM, Sunday ME, Staton GW, Beam WR, King TE. Brief report: idiopathic diffuse hyperplasia of pulmonary neuroendocrine cells and airways disease. N Engl J Med. 1992 Oct 29; 327(18):1285-8. PMID: 1406819.
      View in: PubMed
    55. Aguayo SM, King TE, Kane MA, Sherritt KM, Silvers W, Nett LM, Petty TL, Miller YE. Urinary levels of bombesin-like peptides in asymptomatic cigarette smokers: a potential risk marker for smoking-related diseases. Cancer Res. 1992 May 01; 52(9 Suppl):2727s-2731s. PMID: 1563004.
      View in: PubMed
    56. Aguayo SM, King TE, Waldron JA, Sherritt KM, Kane MA, Miller YE. Increased pulmonary neuroendocrine cells with bombesin-like immunoreactivity in adult patients with eosinophilic granuloma. J Clin Invest. 1990 Sep; 86(3):838-44. PMID: 2394833.
      View in: PubMed
    57. Aguayo SM, Kane MA, King TE, Schwarz MI, Grauer L, Miller YE. Increased levels of bombesin-like peptides in the lower respiratory tract of asymptomatic cigarette smokers. J Clin Invest. 1989 Oct; 84(4):1105-13. PMID: 2794048.
      View in: PubMed
    58. Miller YE, Minna JD, Gazdar AF. Lack of expression of aminoacylase-1 in small cell lung cancer. Evidence for inactivation of genes encoded by chromosome 3p. J Clin Invest. 1989 Jun; 83(6):2120-4. PMID: 2542383.
      View in: PubMed
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